Effect of Tremella fuciformis on the Neurite Outgrowth of PC12h Cells and the Improvement of Memory in Rats(Pharmacology)
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概要
- 論文の詳細を見る
We investigated the neuritogenic effects of Tremella fudformis (TF), which has been valued in traditional Chinese medicine as a remedy with nutritive and tonic actions, on PC12h cells. The cognitive improving effects of TF on scopolamine-induced (2 mg/kg, s.c.) amnesia in rats were also evaluated with using the Morris water maze task and by performing choline acetyltransferase (ChAT) immunohistochemistry. The water extract of TF (0.01-1μg/ml) promoted neurite outgrowth of the PC12h cells in a dose dependent manner. TF was highly efficient at the concentration range of 0.1-1μg/ml. Oral daily treatment with TF (100 or 400 mg/kg) for 14 consecutive days significantly reversed the scopolamine-induced deficit in learning and memory, and it alleviated decrease in cholinergic immunoreactivity induced by scopolamine in the medial septum and hippocampus. The results demonstrate that the promotion of neuritogenesis in neuronal culture cells by TF water extract is related with its activity for improving the performance of rats on a spatial learning and memory task. Moreover, the impairments of spatial learning and memory may be attributable to the decrease in activation of the septohippocampal cholinergic system and that TF ameliorated learning and memory deficits partly through its increasing the central cholinergic activity. Therefore, TF could represent a potentially useful agent that is able to improve the function of impaired cognitive processes.
- 公益社団法人日本薬学会の論文
- 2007-04-01
著者
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KIM Ji
Department of Polymer Science and Engineering, Kumoh National Institute of Technology
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Kim Ji
韓国
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Kim Hyun-su
R&d Center For Functional Foods Institute Of Food And Culture Pulmuone Co. Ltd.
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SHIM Insop
Department of Integrative Medicine, College of Medicine, The Catholic University of Korea
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Shim Insop
Department Of Integrative Medicine College Of Medicine The Catholic University Of Korea
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Shim Insop
Department Of Integrative Medicine Immunology And Cell Biology Core Lab College Of Medicine The Cath
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Kim Ji
Department Of Integrative Medicine Immunology And Cell Biology Core Lab College Of Medicine The Cath
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Kim Ji
Department Of Anesthesiology And Pain Medicine Gachon Medical School Gil Medical Center
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Kang Jung-il
R&d Center For Functional Foods Institute Of Food And Culture Pulmuone Co. Ltd.
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PYUN Kwang-Ho
Department of Integrative Medicine, College of Medicine, The Catholic University of Korea
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HA Hyo-Cheol
R&D Center for Functional Foods, Institute of Food and Culture, Pulmuone Co., Ltd.
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LEE Min-Sook
R&D Center for Functional Foods, Institute of Food and Culture, Pulmuone Co., Ltd.
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KANG Jung-Il
R&D Center for Functional Foods, Institute of Food and Culture, Pulmuone Co., Ltd.
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KIM Hyun-Su
R&D Center for Functional Foods, Institute of Food and Culture, Pulmuone Co., Ltd.
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LEE Sang-Yun
R&D Center for Functional Foods, Institute of Food and Culture, Pulmuone Co., Ltd.
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Pyun Kwang-ho
Department Of Integrative Medicine College Of Medicine The Catholic University Of Korea
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Pyun Kwang-ho
Department Of Integrative Medicine Immunology And Cell Biology Core Lab College Of Medicine The Cath
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Lee Sang-yun
R&d Center For Functional Foods Institute Of Food And Culture Pulmuone Co. Ltd.
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Ha Hyo-cheol
R&d Center For Functional Foods Institute Of Food And Culture Pulmuone Co. Ltd.
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Lee Min-sook
R&d Center For Functional Foods Institute Of Food And Culture Pulmuone Co. Ltd.
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Kim Ji
Department of Advanced Materials Engineering, Sangju National University, Kyeongbuk 742-711, Korea
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