The New Function of Two Ubiquitin C-Terminal Hydrolase Isozymes as Reciprocal Modulators of Germ Cell Apoptosis

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概要

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• Ubiquitination is required throughout all developmental stages of mammalian spermatogenesis. The two ubiquitin C-terminal hydrolase (UCH) enzymes, UCH-L1 and UCH-L3, deubiquitinate ubiquitin-protein conjugates and control the cellular balance of ubiquitin. These two UCH isozymes have 52% amino acid identity and share significant structural similarity. A new function of these two closely related UCH enzymes during spermatogenesis which is associated with germ cell apoptosis has been analyzed. Apoptosis, in general, is thought to be partly regulated by the ubiquitin-proteasome system. During spermatogenesis, apoptosis controls germ cell numbers and eliminates defective germ cells to facilitate testicular homeostasis. In this paper, I review the distinct function of the two UCH isozymes in the testis of gad and Uchl3 knockout mice, which are strongly but reciprocally expressed during spermatogenesis. In addition, the importance of UCHL1-dependent apoptosis for normal spermatogenesis and sperm quality control is discussed.

• Japanese Association for Laboratory Animal Scienceの論文

著者

• Kwon Jungkee

  Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of

関連論文

• Immunohistochemical Analysis of Protein Gene Product 9.5, a Ubiquitin Carboxyl-terminal Hydrolase, during Placental and Embryonic Development in the Mouse
• Characterization of the Testis in Congenitally Ubiquitin Carboxy-Terminal Hydrolase-1 (Uch-L1) Defective (gad) Mice
• The Region-Specific Functions of Two Ubiquitin C-Terminal Hydrolase Isozymes along the Epididymis
• ユビキチンのC末端加水分解酵素欠損は骨石灰化を減少させる(生理学)
• The New Function of Two Ubiquitin C-Terminal Hydrolase Isozymes as Reciprocal Modulators of Germ Cell Apoptosis

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