Immunohistochemical Localization of Relaxin and Its Receptors in Salivary Gland Tumors: A Preliminary Analysis
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概要
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Relaxin is a short circulating peptide hormone, and the major stored and circulatory form in humans is relaxin-2, generally known to have hormogenic functions and to act as an antifibrotic factor during childbirth in females. Relaxin is also expressed in mammary gland tissue and its tumors, suggesting association with tumorigenesis and development in exocrine tissues. In addition, leucine-rich repeat containing G protein-coupled receptors（LGR）7 and LGR8 are known to be receptors for relaxin. To understand the biological role of relaxin, it is necessary to determine the distribution pattern of both relaxin and its related receptors. Therefore, we performed a preliminary immunohistochemical analysis of relaxin and the receptors in salivary gland tumors comprising pleomorphic adenomas, Warthin tumors, adenoid cystic carcinomas, mucoepidermoid carcinomas and submandibular gland tissues.The immunohistochemical findings showed positive immunoreactivity for relaxin-2 in the ductal, myoepithelial and/or basaloid cells in pleomorphic adenomas, Warthin tumors, adenoid cystic carcinomas, mucoepidermoid carcinomas, and in duct, myoepithelial and serous acinar cells in the submandibular glands.These results suggest that localization and binding of relaxin-2 and receptors such as LGR7 and LGR8 are associated with ductal and tubular growth of the tumors, as well as the maintenance of duct formation, in salivary gland tumors and submandibular gland tissues.
- 日本大学松戸歯学部 口腔科学研究所の論文
著者
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Ito Rie
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Kasai Kazutaka
Department Of Orthodontics Graduate School Of Dentistry At Matsudo Nihon University
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Yamaguchi Masaru
Department Of Chemistry Faculty Of Science Kyushu University
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Utsunomiya Tadahiko
Department Of Oral Pathology Nihon University School Of Dentistry At Matsudo
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Ito Rie
Departments of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
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Yamamoto Hirotsugu
Nihon University
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Yamaguchi Masaru
Departments of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
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