Analysis of Drugs of Abuse in Biological Specimens
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概要
- 論文の詳細を見る
Recent reports of the analysis of drugs of abuse in biological specimens are reviewed herein. Different perspectives from reviews so far published and the need for and the background of drug analysis in biological specimens, and difficulty of drug testing in biological specimens are introduced. Comprehensive biological specimens for the analysis of drugs of abuse in forensic science, including oral fluid (saliva), hair, umbilical cord, placenta, meconium, cadaver tissue (brain, adipose), sweat, breath, and nail clippings, in addition to the commonly used blood and urine specimens in clinical chemistry, are described along with their outlines, advantages/disadvantages, and actual examples. Today, liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the method of choice for the analysis of drugs of abuse. A simultaneous screening method for multiple types of drugs has also become popular recently. However, because qualitative determination remains important in forensic science, gas chromatography-mass spectrometry (GC-MS) is still in use even if it requires complicated specimen preparation and derivatization procedures. This is because GC-MS is reliable and has been employed ever since for the appraisal of trials.
著者
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岩崎 雄介
星薬科大学薬品分析化学教室
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Iwasaki Yusuke
Deparment of Cardiology, Osaka General Medical Center
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Ito Rie
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Nakazawa Hiroyuki
Department Of Analytical Chemistry Faculty Of Pharmaceutical Science Hoshi University
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Saito Koichi
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto Prefectural University
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Ito Rie
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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岩崎 雄介
星薬科大学薬学部薬品分析化学教室
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Saito Rieko
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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Kikuchi Yuu
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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