An Approach for Decontamination of β-Lactam Antibiotic Residues or Contaminants in the Pharmaceutical Manufacturing Environment
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概要
- 論文の詳細を見る
An effective procedure for decontamination of β-lactam antibiotic residues or contaminants in the pharmaceutical manufacturing environment was investigated. Decontamination with solutions of hydrochloric acid, sodium hydroxide, hydrogen peroxide and hydroxylamine as agents for degradation was assessed. According to the results, the β-lactam antibiotics were significantly degraded with sodium hydroxide and hydroxylamine. From the structural analysis of the degradation products of a cephem antibiotic, cefpodoxime proxetil, it was found that hydroxylamine degraded the β-lactam structure under mild conditions, while sodium hydroxide did not. Therefore, hydroxylamine was considered an appropriate decontamination agent for β-lactam antibiotics.
- 公益社団法人日本薬学会の論文
- 2006-09-01
著者
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NAKAZAWA Hiroyuki
Department of Analytical Chemistry, Hoshi University
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SAITO Koichi
Department of Bioregulation, Biomedical Research Center, Osaka University Graduate School of Medicin
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Saito Koichi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Kawasaki Takao
Analytical And Quality Evaluation Research Laboratories Sankyo Co. Ltd.
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Nakazawa Hiroyuki
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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FUKUTSU Naoto
Analytical and Quality Evaluation Research Laboratories, Sankyo Co., Ltd.
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Fukutsu Naoto
Analytical And Quality Evaluation Research Laboratories Sankyo Co. Ltd.
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Nakazawa Hiroyuki
Department Of Analytical Chemistry Faculty Of Pharmaceutical Science Hoshi University
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Saito Koichi
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto Prefectural University
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Nakazawa Hiroyuki
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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