Study of Compounds Suppressing Free Radical Generation from UV-Exposed Ketoprofen
スポンサーリンク
概要
- 論文の詳細を見る
Ketoprofen [(RS)-2-(3-benzoylphenyl)propanoic acid] is widely used for the treatment of inflammatory diseases and musculoskeletal injury. However, there is concern regarding its potential for photosensitization as a side effect. Free radicals and active oxygen species generated from ketoprofen on exposure to ultraviolet (UV) light have been implicated in phototoxicity and photosensitization. In this study, we examined the suppressing ability of some compounds for the free radicals and active oxygen species generated by the photodynamic reaction of ketoprofen, to determine a new resist of photosensitization by ketoprofen. Eight compounds, including six known free radical scavengers were individually mixed with ketoprofen, and the mixtures were exposed to UV. Then, the free radicals and the active oxygen species were determined by the electron spin resonance spectrometry to estimate suppressing and scavenging ability of compounds. The compounds that show promise in suppressing superoxide anion generation from UV-exposed ketoprofen were further evaluated using the on-line photo-irradiated superoxide anion detection system. It was confirmed that quercetin, a flavonoid, strongly suppresses the generation of free radicals and active oxygen species from UV-exposed ketoprofen. The experiments using the experimental formulation of an adhesive skin patch of ketoprofen containing quercetine and the Chemiluminescence analyzer (CLA) indicated that quercetin has high potential for use as an excipient in ketoprofen ointments to suppress phototoxicity and photosensitization by ketoprofen.
- 公益社団法人日本薬学会の論文
- 2007-10-01
著者
-
Yoshimura Yoshihiro
Nihon Integrative Medicine Institute
-
NAKAZAWA Hiroyuki
Department of Analytical Chemistry, Hoshi University
-
Tahara Maiko
Department Of Analytical Chemistry Hoshi University
-
Yoshimura Yoshihiro
国立医薬品食品衛生研究所 病理部
-
Nakajima Ayako
Department Of Analytical Chemistry Hoshi University
-
Nakazawa Hiroyuki
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
-
Yoshimura Yoshihiro
Nihon Integrative Medicine Inst.
-
Nakazawa Hiroyuki
Department Of Analytical Chemistry Faculty Of Pharmaceutical Science Hoshi University
関連論文
- In Vitro Physicochemical Properties of Neutral Aqueous Solution Systems (Water Products as Drinks) Containing Hydrogen Gas, 2-Carboxyethyl Germanium Sesquioxide, and Platinum Nanocolloid as Additives
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- Studies on the physicochemical properties and existence of water products (as drinks) advertised as having smaller cluster sizes of H2O molecules than those of regular water
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- 10. 新生児, 乳児における消化管奇形の手術成績について(新生児消化管 I)
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- Analysis of Active Oxon Forms of Nine Organophosphorus Pesticides in Water Samples Using Gas Chromatography with Mass Spectrometric Detection
- Studies on the Physicochemical Properties and Existence of Water Products (as Drinks) Advertised as Having Smaller Cluster Sizes of H2O Molecules than Those of Regular Water
- Two Sensitive Sick-building Syndrome Patients Possibly Responding to p-Dichlorobenzene and 2-Ethyl-1-Hexanol : Case Report
- Development of sensitive high-performance liquid chromatography with fluorescence detection using 4-(4, 5-diphenyl-1H-imidazol-2-yl)-benzoly chloride as a labeling reagent for determination of bisphenol A in plasma samples
- Contribution of Glutathione Peroxidase and Nitric Oxide to Potassium Bromate-Induced Oxidative Stress and Kidney Damage in Mice
- pH-DEPENDENT AND cAMP-INDEPENDENT PHOSPHORYLATION OF AXONEMAL PROTEINS ASSOCIATED WITH FLAGELLAR MOTILITY ACTIVATION OF STARFISH SPERM(Cell Biology and Morphology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Jap
- CA^-BINDING PROTEIN REGULATES FLAGELLAR MOTILITY IN EURYHALINE TILAPIA (OREOCHROMIS MOSSAMBICUS)(Cell Biology and Morphology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- FLAGELLAR MOTILITY ACTIVATION MEDIATED BY THE INCREASE IN INTRACELLULAR pH AND THE RELATED PROTEIN PHOSPHORYLATION OF FLAGELLA IN STARFISH SPERMATOZOA(Cell Biology and Morphology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoologica
- LOCALIZATIONS OF PHOSPHO-PROTEINS OF EURYHALINE TILAPIA (OREOCHROMISS MOSSAMBICUS) SPERM FLAGELLA(Cell Biology and Morphology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- PROTEIN PHOSPHORYLATION DURING MOTILITY ACTIVATION IN STARFISH (ACANTHASTER PLANCI) SPERMATOZOA(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- PROTEIN PHOSPHORYLATION ON MOTILITY ACTIVATION IN SPERMATOZOA OF THE STARFISH, ACANTHASTER PLANCI(Cell Biology and Morphology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Simultaneous Doping Analysis of Main Urinary Metabolites of Anabolic Steroids in Horse by Ion-trap Gas Chromatography-Tandem Mass Spectrometry
- Stir bar sorptive extraction with in situ derivatization and thermal desorption-gas chromatography-mass spectrometry for measurement of phenolic xenoestrogens in human urine samples
- Stir bar sorptive extraction and thermal desorption-gas chromatography-mass spectrometry for the measurement of 4-nonylphenol and 4-tert-octylphenol in human biological samples
- Analysis of the metabolites of the sodium salt of 6-hydroxy-5- (phenylazo) -2-naphthalenesulfonic acid in Sprague-Dawley rat urine
- Determination of uric acid in human saliva by high-performance liquid chromatography with amperometric electrochemical detection
- Determination of perfluorooctane sulfonate, perfluorooctanoate and perfluorooctane sulfonylamide in human plasma by column-switching liquid chromatography-electrospray mass spectrometry coupled with solid-phase extraction
- Determination of three phthalate metabolites in human urine using on-line solid-phase extraction-liquid chromatography-tandem mass spectrometry
- Epigenetic Assessment of Environmental Chemicals Detected in Maternal Peripheral and Cord Blood Samples
- Study of Compounds Suppressing Free Radical Generation from UV-Exposed Ketoprofen
- Development of Miniaturized Hollow-fiber Assisted Liquid-phase Microextraction with in situ Acyl Derivatization Followed by GC-MS for the Determination of Benzophenones in Human Urine Samples
- Measurement of Benzophenones in Human Urine Samples by Stir Bar Sorptive Extraction and Thermal Desorption-Gas Chromatography-Mass Spectrometry
- Determination of Benzophenones in River-water Samples Using Drop-based Liquid Phase Microextraction Coupled with Gas Chromatography/Mass Spectrometry
- Analysis of glutathione and glutathione disulfide in human saliva using hydrophilic interaction chromatography with mass spectrometry
- Determination of bisphenol A in river water and body fluid samples by stir bar sorptive extraction with in situ derivatization and thermal desorption-gas chromatography-mass spectrometry
- Verification of Cefmetazole and Cefpodoxime Proxetil Contamination to Other Pharmaceuticals by Liquid Chromatography-Tandem Mass Spectrometry
- An Approach for Decontamination of β-Lactam Antibiotic Residues or Contaminants in the Pharmaceutical Manufacturing Environment
- Hollow-fiber-supported liquid phase microextraction with in situ derivatization and gas chromatography-mass spectrometry for determination of chlorophenols in human urine samples
- Determination of urinary triclosan by stir bar sorptive extraction and thermal desorption-gas chromatography-mass spectrometry
- Chromatographic and mass spectrometric analysis of glutathione in biological samples
- Miniaturized hollow fiber assisted liquid-phase microextraction and gas chromatography-mass spectrometry for determination of benzophenone and derivates in human urine sample
- Miniaturized hollow fiber assisted liquid-phase microextraction with in situ derivatization and gas chromatography-mass spectrometry for analysis of bisphenol A in human urine sample
- Identification and Detection Method for Genetically Modified Papaya Resistant to Papaya Ringspot Virus YK Strain
- Highly Sensitive Reporter Gene Assay for Dioxins in Human Plasma by Using Cycloheximide as an Enhancer Substance
- MUTUAL DETERMINATION OF ORTHOPHOSPHATE AND ARSENATE WITH A DUAL-WAVELENGTH SPECTROPHOTOMETER BASED ON THE FORMATION OF THE HETEROPOLY BLUES
- Epigenetic Assessment of Environmental Chemicals Detected in Maternal Peripheral and Cord Blood Samples
- Analysis of Drugs of Abuse in Biological Specimens