Verification of Cefmetazole and Cefpodoxime Proxetil Contamination to Other Pharmaceuticals by Liquid Chromatography-Tandem Mass Spectrometry
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概要
- 論文の詳細を見る
Cross-contamination is a critical issue for pharmaceutical manufacturing, especially for β-laetam antibiotics. Thus, an analytical method for the simultaneous determination of β-lactam antibiotics cefmetazole (CMZ) and cefpodoxime proxetil (CPDXPR) contaminants in non-β-lactam pharmaceuticals was developed using high-performance liquid chromatography-tandem mass spectrometry. The developed method was found to be sensitive at the detection limit of 0.002 ppm for both compounds. Mean recoveries of CMZ and CPDXPR from olmesartan medoxomil (OLM) tablets were 96.7 to 102.2% and 88.9 to 94.2%, respectively. The developed method was successfully applied for the verification of CMZ and CPDXPR contamination to actually manufactured OLM tablets.
- 公益社団法人日本薬学会の論文
- 2006-10-01
著者
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NAKAZAWA Hiroyuki
Department of Analytical Chemistry, Hoshi University
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SAITO Koichi
Department of Bioregulation, Biomedical Research Center, Osaka University Graduate School of Medicin
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Saito Koichi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Kawasaki Takao
Analytical And Quality Evaluation Research Laboratories Sankyo Co. Ltd.
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Nakazawa Hiroyuki
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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FUKUTSU Naoto
Analytical and Quality Evaluation Research Laboratories, Sankyo Co., Ltd.
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SAKAMAKI Yuich
Quality Control Section, Hiratsuka Plant, Sankyo Co., Ltd.
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Fukutsu Naoto
Analytical And Quality Evaluation Research Laboratories Sankyo Co. Ltd.
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Sakamaki Yuich
Quality Control Section Hiratsuka Plant Sankyo Co. Ltd.
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Nakazawa Hiroyuki
Department Of Analytical Chemistry Faculty Of Pharmaceutical Science Hoshi University
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Saito Koichi
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto Prefectural University
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Nakazawa Hiroyuki
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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