IL-6 and IL-17 in the Gingival Crevicular Fluid During Orthodontic Root Resorption
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概要
- 論文の詳細を見る
Objectives : Root resorption is an unwanted effect of orthodontic tooth movement. An analysis of the cytokines in gingival crevicular fluid (GCF) is a potentially safer method of quantifying root resorption compared with conventional radiographic methods. This study aimed to quantify the levels of interleukin-6 (IL-6) and 17 (IL-17), released into the GCF during physiological root resorption and orthodontic tooth movement.Materials and Methods : Subjects with severe root resorption (>1/3 of the original root length) were identified. A control group comprising subjects with no loss of the root structure or undergoing orthodontic treatment was also identified. Gingival crevicular fluid (GCF) was collected non-invasively from the mesial and distal sides of each of the four upper incisors by using filter paper strips. The eluted GCF was used for an enzyme-linked immunosorbent assay (ELISA) and a Western blot analysis. The antibodies used were specific for IL-6 and IL-17.Results : The ELISA results with IL-6 and IL-17 antibodies showed statistically significant differences between the control group and the root resorption group. The Western blot analysis showed differential expression of IL-6 and IL-17 in the control and root resorption subjects.Conclusions : These results confirm the presence of cytokines in the GCF of root resorbed subjects. The results highlight the potential for measuring IL-6 and IL-17 in the GCF as a biomarker to monitor root resorption.
著者
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Fujita Shoji
Department Of Cardiovascular Respiratory & Metabolic Medicine Graduate School Of Medicine Kagosh
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Hayashi Noriko
Department Of Applied Biology Kyoto Institute Of Technology
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Kasai Kazutaka
Department Of Orthodontics Graduate School Of Dentistry At Matsudo Nihon University
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Nakajima Ryo
Department Of Chemistry And Chemical Biology Gunma University
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Yamaguchi Masaru
Department Of Chemistry Faculty Of Science Kyushu University
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Yamaguchi Yoshihiro
Department Of Chemistry Faculty Of Science And Technology Kinki University
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Hayashi Noriko
Department of Orthodontics, Nihon University School of Dentistry at Matsudo
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Nariyasu Takashi
Department of Orthodontics, Nihon University School of Dentistry at Matsudo
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