Diastereoselective reduction of .ALPHA.-keto amides having trans-2,5-disubstituted pyrrolidine as a chiral auxiliary.
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概要
- 論文の詳細を見る
The reduction of α-keto amides derived from (2<I>R</I>,5<I>R</I>)-<I>trans</I>-2,5-bis(methoxymethoxymethyl)pyrrolidine [(<I>R</I>)-BMOMP, <B>1</B>] with LiBEt<SUB>3</SUB>H or KBEt<SUB>3</SUB>H proceeded with high diastereoselectivity (up to 99% ds) to afford the corresponding α-hydroxy amides in good yields. The additive effect of crown ethers or metallic salts on the stereoselectivity was also examined.
- 公益社団法人 日本化学会の論文
著者
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Katsuki Tsutomu
Department Of Chemistry Faculty Of Science Graduate School Kyushu University
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Kawanami Yasuhiro
Department Of Applied Biological Science Faculty Of Agriculture Kagawa University
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Fujita Izumi
Department Of Surgery Institute Of Gastroenterology Tokyo Women's Medical University
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Yamaguchi Masaru
Department Of Chemistry Faculty Of Science Kyushu University
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Asahara Shouko
Department of Chemistry, Faculty of Education, Kagawa University
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