IDENTIFICATION OF 7β-HYDROXY METABOLITES OF DEHYDROCHOLATE IN MAN AND RAT(Communications to the Editor)
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概要
- 論文の詳細を見る
Dehydrocholic acid was administered intravenously to a patient and to rats, and its metabolites excreted into bile were studied by gas chromatography-mass spectrometry as ethyl ester-dimethylethylsilyl ether-methyloxime derivatives. Two 7β-hydroxy metabolites were identified: 3α,7β-dihydroxy-12-oxo-5β-cholanoic acid in both human and rat bile, and 3α,7β,12α-trihydroxy-5β-cholanoic acid in rat bile. This indicates that human and rat livers are able to reduce the 7-oxo group in dehydrocholic acid to both 7α- and 7β-hydroxy forms.
- 公益社団法人日本薬学会の論文
- 1987-09-25
著者
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ICHIMIYA HITOSHI
Department of Pathology II, Kyushu University Faculty of Medicine
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Ichimiya Hitoshi
Division Of Surgery Hamanomachi General Hospital
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Ichimiya Hitoshi
Department Of Cardiology Aichi Cardiovascular And Respiratory Center
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Ichimiya Hitoshi
Department Of Surgery I Kyushu University Faculty Of Medicine
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Miyazaki Yasuhiro
Department of Surgery I, Kyushu University Faculty of Medicine
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Miyazaki Hiroshi
Nippon Kayaku Co., Ltd.
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Nakayama Fumio
Department of Surgery I, Kyushu University Faculty of Medicine
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Nakagawa Mitsuru
Department of Surgery I, Kyushu University Faculty of Medicine
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Nakayama F
Department Of Surgery I Kyushu University Faculty Of Medicine
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Miyazaki Yasuhiro
Department Of Surgery I Kyushu University Faculty Of Medicine
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Nakagawa Mitsuru
Department Of Surgery I Kyushu University Faculty Of Medicine
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Miyazaki Hiroshi
Nippon Kayaku Co. Ltd.
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NAKAGAWA Mitsuru
Department of Geology and Mineralogy, Hokkaido University
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MIYAZAKI Yasuhiro
Department of Agricultural Chemistry, Faculty of Agriculture, Utsunomiya University
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