Dose-Dependent Effect of Dietary Conjugated Linoleic Acid on the Growth of Rat Hepatoma dRLh-84 Cells In Vivo
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概要
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In this study, the effect of varying doses of conjugated linoleic acid (CLA) on the growth of transplanted hepatoma dRLh-84 cells and the relationship between tumor growth and prostaglandin (PG) E2 production or cyclooxygenase (COX)-2 expression were examined. Donryu rats were fed an experimental diet containing 0, 0.1, 0.5, or 2 wt.% CLA for 3 wk, and then dRLh-84 cells were transplanted into the liver. Results show that dietary CLA (0.5 and 2 wt.%) significantly enhanced the growth of the transplanted hepatoma cells compared to the non-CLA diet group at 20 d after cell transplantation. Tumor weight at 10 d after transplantation was also significantly higher in the 2 wt.% CLA group than in non-CLA fed rats. Ten days after transplantation, the PGE2 level in the tumor tissue was shown to be depressed in a CLA dose-dependent manner. Cyclooxygenase-2 (COX-2) mRNA expression in the tumor also tended to be lower in the CLA group than in the non-CLA diet group 10 d after transplantation. Dietary CLA did not affect the tumor phospholipid arachidonic acid level, which is a substrate for PG synthesis. These results indicate that dietary CLA of at least 0.5 wt.% enhances the growth of transplanted dRLh-84 cells in vivo. It is believed that growth promotion of dRLh-84 cells in vivo by CLA cannot be clarified by the PG synthesis dependent mechanism.
- 財団法人 学会誌刊行センターの論文
著者
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Hirao Akira
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Shimada Mitsuo
Department Of Digestive And Pediatric Surgery Institute Of Health Biosciences University Of Tokushim
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YAMASAKI Masao
Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and
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RIKIMARU Tatsuya
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
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IKEDA Atsushi
Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and
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SUGIMACHI Keizo
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
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Tachibana Hirofumi
Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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Sugimachi Keizo
Department Of Chest Surgery National Kyushu Cancer Center Graduate School Of Medicine Kyushu Univers
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Yamada Koji
Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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Rikimaru Tatsuya
Department Of Surgery And Science Graduate School Of Medical Sciences Kyushu University
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Tanaka Yoko
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University
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TACHIBANA Hirofumi
Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
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HIRAO Akira
Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
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YAMASAKI Masao
Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
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