Association Between Blood Pressure Variability and Inflammatory Marker in Hypertensive Patients

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• Background Blood pressure (BP) variability has been reported to be associated with hypertensive target organ damage and cardiovascular events. However, the exact mechanism linking BP variability and organ damage is uncertain. This study was designed to investigate the association between BP variability and inflammatory marker in hypertensive patients. Methods and Results Fifty-two hypertensive patients (28 men, 55.9±1.5 years) completed 24-h ambulatory BP monitoring. Inflammatory markers were evaluated by measuring plasma levels of interleukin (IL)-6, tumor necrosis factor (TNF)-α by enzyme-linked immunosorbent assay and high sensitive C-reactive protein (hs-CRP) by particle-enhanced light-scattering immunoassay. BP variability was obtained by calculating within-subject standard deviation (SD) and coefficient of variation of BP. Subjects were grouped into tertiles according to IL-6, TNF-α, and hs-CRP levels. A significant association between ambulatory BP and TNF-a level was identified (P for trend =0.011). In contrast, no association was observed between BP and IL-6 level; however, BP variability index was linked to IL-6 level (P for trend =0.046). The association between inflammatory marker and pattern of diurnal variation was investigated. The hs-CRP concentration was significantly higher in the riser group compared with the dipper group. However, IL-6 and TNF-a levels did not differ among the different diurnal variation groups. Correlation analysis showed varying associations between IL-6 and TNF-α level correlated with the BP index; however, IL-6 level correlated with the BP variability index. Multiple linear regression models revealed that the SD of daytime systolic BP (β=0.065, p=0.001) and age (β=0.024, p=0.016) were all positively and significantly related to IL-6. In contrast, only daytime diastolic BP (β=0.029, p=0.002) was independently related to TNF-α. Conclusion Inflammatory markers are associated with BP variability in hypertensive patients. This finding implies that inflammation may be a mediator for the link between BP variability and target organ damage.

• 社団法人日本循環器学会の論文
• 2008-01-20

著者

• Youn Tae-jin

  韓国

• Youn T‐j

  Bundang Hospital College Of Medicine Seoul National University

• Yeon Tae-jin

  韓国

• Choi Dong-joo

  Bundang Hospital College Of Medicine Seoul National University

• Park Kyung

  Department Of Laboratory Medicine Seoul National University College Of Medicine:seoul National Unive

• Park Kyung-woo

  韓国

• Park Keun-Ho

  Seoul National University Hospital

• KIM Kwang-Il

  Department of Internal Medicine, Seoul National University College of Medicine, Seoul National Unive

• CHO Young-Seok

  Department of Internal Medicine, Seoul National University College of Medicine, Seoul National Unive

• CHOI Dong-Ju

  Department of Internal Medicine, Seoul National University College of Medicine, Seoul National Unive

• KIM Cheol-Ho

  Department of Internal Medicine, Seoul National University College of Medicine, Seoul National Unive

• Lee Jae-Hee

  Seoul National University Bundang Hospital

• Chang Hyuk-Jae

  Department of Internal Medicine, Seoul National University College of Medicine

• Youn Tae-Jin

  Department of Internal Medicine, Seoul National University College of Medicine

• Chung Woo-Young

  Department of Internal Medicine, Seoul National University College of Medicine

• Chae In-Ho

  Department of Internal Medicine, Seoul National University College of Medicine

• Park Kyoung

  Department of Laboratory Medicine, Seoul National University College of Medicine

• Kim Cheol-Ho

  Seoul National University Bundang Hospital

• Chae In-ho

  Bundang Hospital College Of Medicine Seoul National University

• Choi Yun

  Department Of Internal Medicine Seoul National University College Of Medicine

• Cho Young-seok

  Bundang Hospital College Of Medicine Seoul National University

• Park Young-bae

  韓国

• Park Y‐b

  Division Of Cardiology Department Of Internal Medicine Seoul National University College Of Medicine

• Chung Woo-young

  Department Of Internal Medicine Seoul National University College Of Medicine

• Kim Kwang-il

  Department Of Internal Medicine Seoul National University College Of Medicine Seoul National Univers

• Cho Young-seok

  Department Of Internal Medicine Seoul National University College Of Medicine Seoul National Univers

• Chae In-ho

  Department Of Internal Medicine Seoul National University College Of Medicine

• Kim C‐h

  Seoul National University Bundang Hospital

• Kim Cheol-ho

  韓国

• Youn Tae-jin

  Department Of Cardiology Chungbuk National University Hospital

• Kim Kwang-il

  Seoul National University Bundang Hospital

• Park Keun-ho

  Department Of Laboratory Medicine Seoul National University College Of Medicine:seoul National Unive

• Park Keun-ho

  韓国

• Choi Dong-ju

  Bundang Hospital College Of Medicine Seoul National University

• PARK Kyung-Woo

  Jeju self-government province

• CHO Young-Seok

  Jeju self-government province

• Park Kyung

  韓国

• Chung Woo-young

  Department Of Internal Medicine And Cardiovascular Center Seoul National University Bundang Hospital

• Choi Dong-ju

  Department Of Internal Medicine Seoul National University College Of Medicine Seoul National Univers

• Park Hyo

  韓国

• Chang Hyuk-jae

  Department Of Internal Medicine Seoul National University College Of Medicine

• Park Young-bae

  Division Of Cardiology Department Of Internal Medicine College Of Medicine Seoul National University

• Chae In-ho

  Seoul National University College Of Medicine Cardiovascular Center Seoul National University Bundan

• Kim Kwang-il

  Department Of Internal Medicine Seoul National University College Of Medicine

• Park Young

  Division Of Cardiology Department Of Internal Medicine College Of Medicine Seoul National University

• Kim Cheol-ho

  Department Of Internal Medicine Seoul National University College Of Medicine Seoul National Univers

• Park Kyoung

  Department Of Dermatology Clinical Research Institute Seoul National University Hospital College Of

• Park K‐w

  Jeju Self-government Province

• Kim Cheol-ho

  Department Of Biological Sciences College Of Natural Science Sungkyunkwan University

• Cho Young-seok

  Department Of Internal Medicine Seoul National University College Of Medicine Seoul National Univers

• Cho Young-seok

  Department Of Internal Medicine Seoul National University College Of Medicine

• PARK Kyoung

  Department of Biology, SungShin Women's University

• Chang Hyuk-Jae

  Department of Cardiology, Ajou University School of Medicine

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