Evaluation of Metabolic Syndrome Risk in Korean Premenopausal Women : Not Waist Circumference but Visceral Fat

概要

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Background In clinical practice, using the patient's waist circumference (WC) to evaluate visceral obesity may underestimate disorders with a metabolic origin. This study examined whether or not the WC derived from the cut-off point of the visceral fat area (VFA) can reflect the features of metabolic syndrome (MetS) in premenopausal women. Methods and Results Computed tomography-scanned VFA, MetS components and the concentrations of high-sensitivity C-reactive protein (CRP) and adiponectin were measured in a total of 349 premenopausal women. The VFA at the L1 and the L4 sites was a significant index (p<0.001) of incremental MetS risk. Receiver-operating characteristic curve analysis showed that 75 cm^2 of VFA at L4 and 87.5 cm^2 at L1 were the optimal thresholds for discrimination of MetS risk. Significant differences in all MetS components, as well as CRP (p<0.05) and adiponectin levels (p<0.005), were observed when subjects were subdivided by the L4 VFA cut-off point (<75/>75 cm^2), whereas there was a significant difference only in the triglycerides level in the groups divided by WC (WC <88/≥88 cm). Moreover, subjects with a lower WC-higher VFA showed a similar pattern in MetS components and lower adiponectin than those with a higher WC-higher VFA. Conclusions This study clarified that VFA rather than WC is a major determinant of MetS risk in premenopausal women.
社団法人日本循環器学会の論文
2008-07-20