Carriage of the V279F Homozygous Genotype, a Rare Allele, within the Gene Encoding Lp-PLA2 Leads to Changes in Circulating Intermediate Metabolites in Individuals without Metabolic Syndrome

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概要

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• Aim: Identifying differences in plasma metabolic profiling between Lp-PLA2 279VV and 279FF in individuals without metabolic syndrome (MetS) can be used to elucidate the roles of novel Lp-PLA2 activities in normal physiological processes.Methods: Non-MetS individuals with 279FF (n=36) and age-, sex- and BMI-matched VV subjects (n=36) were included in this analysis.Results: The FF subjects exhibited no appreciable enzyme activity. No significant differences were observed between the VV and FF subjects in the serum lipid profiles or hs-CRP, plasma ox-LDL, MDA or urinary 8-epi-PGF2α levels. The FF subjects also showed lower activities of lyso-phosphatidylcholine (lysoPC) (16:0) (p=0.003) and oleamide (p＜0.001) and a higher activity of L-tryptophan (p=0.016) than the VV subjects. In addition, the Lp-PLA2 activity positively correlated with the lysoPC (16:0) and lysoPC (18:0) activities and negatively correlated with the PC (16:0/22:6) and L-tryptophan activities in the VV subjects. Furthermore, in the VV subjects, the lysoPC (16:0) and lysoPC (18:0) activities negatively correlated with the presence of PCs containing 14:0/20:2, 14:0/22:4 and 16:0/22:6, while the oleamide activity exhibited a strong positive correlation with lysoPCs and a negative correlation with PCs, whereas the relationship between oleamide and lysoPCs and PCs was weaker in the FF subjects.Conclusions: The present results indicate that the natural absence of the plasma Lp-PLA2 activity due to carriage of the Lp-PLA2 279FF genotype may reduce the generation of lysoPC (16:0) and oleamide and thereby enhance the activity of plasma tryptophan in normal physiological processes.

• 一般社団法人 日本動脈硬化学会の論文

著者

• Lee Sang-hyun

  Department Of Chemical And Biomolecular Engineering Korea Advanced Institute Of Science And Technolo

• Lee Jong

  National Center for Nanoprocess and Equipment, Korea Institute of Industrial Technology, Gwangju 500-480, Republic of Korea

• Chae Jey

  Yonsei University Research Institute of Science for Aging, Yonsei University

• Joo Jaehyun

  National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University

• Jung Saem

  National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University

• Kim Minjoo

  National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University

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• Carriage of the V279F Homozygous Genotype, a Rare Allele, within the Gene Encoding Lp-PLA2 Leads to Changes in Circulating Intermediate Metabolites in Individuals without Metabolic Syndrome

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