Antidiabetic Effects of Vigna nakashimae Extract in db/db Mice

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概要

• 論文の詳細を見る

• The inhibitory activity of Vigna nakashimae extract against intestinal α-glucosidase was investigated in vitro and in vivo. The extract exerted a significant inhibitory effect against intestinal α-glucosidases. With sucrose-loading, it reduced the peak responses of blood glucose significantly in normal mice. Next, it was administrated to 8-week-old db/db mice for 2 weeks, and then plasma glucose, triglyceride, and total cholesterol levels were measured. The extract significantly suppressed postprandial hyperglycemia and blood glycated hemoglobin in the db/db mice. In addition, it lowered fasting glucose and improved glucose tolerance. Furthermore, it led to significant decreases in plasma triglyceride levels. It reduced endoplasmic reticulum stress in thapsigargin-induced HepG2 cells. Taken together, these results suggest that Vigna nakashimae extract has hypoglycemic and hypolipidemic effects that occur via inhibition of α-glucosidase activity and endoplasmic reticulum stress.

• 2011-11-23

著者

• Ha Tae

  Department Of Agricultural Chemistry Division Of Applied Life Science Gyeongsang National University

• Ha Tae

  Department Of Functional Crops National Institute Of Crop Science Rda

• Jung Myeong-ho

  School Of Korean Medicine Pusan National University

• YEO Ji

  School of Korean Medicine, Pusan National University

• NAM Jeong-Su

  School of Korean Medicine, Pusan National University

• Nam Jeong-su

  School Of Korean Medicine Pusan National University

• Yeo Ji

  School Of Korean Medicine Pusan National University

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