Acute Changes of Central Corneal Thickness According to Experimental Adjustment of Intraocular Pressure in Normal Canine Eyes

概要

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Central corneal thickness (CCT) can be a promising source of glaucoma monitoring and diagnosis. This study evaluated changes to CCT according to experimental adjustment of intraocular pressure (IOP) in canine eyes. To adjust and measure IOP, each eye was cannulated with two 26-gauge needles under inhalant anesthesia. One needle was connected to a pressure transducer and the other to an adjustable bag of physiologic saline. IOP was stepwise increase from 10 mmHg to 70 mmHg in 10 mmHg increments (Group T). IOP was maintained at 15 mmHg (Group C15), 30 mmHg (Group C30), 45 mmHg (Group C45), 60 mmHg (Group C60) and 75 mmHg (Group C75) during the experiment. CCT was measured with an ultrasonic pachymeter every 10 mins after the cannulation. There was a significant difference in effect of the time on CCT (P<0.001) and difference in CCT (dCCT; P<0.001) between groups. The CCT of group C15 remained constant during the experiment. However, groups T showed an initial decrease and then an increase after passing a lowest point. Group C30 showed decreasing values for 30 mins, after which values remained constant. Group C45 was not changed for 40 min and then increased. Group C60 was not changed for 20 min and then increased. Group C75 showed a steady increase. In conclusion, the CCT showed two core changes according to increased IOP. This study provides essential basic data to enable further investigation into the association of IOP and CCT in dogs.