Nocapyrones H-J, 3,6-disubstituted a-pyrones from the Marine Actinomycete Nocardiopsis sp. KMF-001

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概要

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• Three new 3,6-disubstituted a-pyrones, nocapyrones H-J (1-3), were isolated from the marine actinomycete Nocardiopsis sp. KMF-001. Their structures were assigned to be 3-alkylated 6-(1-methyl-1-propenyl)-2H-pyran-2-ones on the basis of UV, MS, NMR, and HRFABMS analyses. Nocapyrone H (1) reduced the pro-inflammatory factor such as nitric oxide (NO), prostaglandin E2(PGE2) and interleukin-1β (IL-1β). Moreover, nocapyrone H showed 5.82% stronger inhibitory effect on NO production than chrysin at a concentration of 10 μM in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells.

著者

• Kwon Hak

  Natural Products Laboratory College Of Pharmacy Sung Kyun Kwan University

• Park Jin-soo

  Natural Products Research Center Korea Institute Of Science And Technology

• Kim Sun

  Department Of Animal Science And Technology Seoul National University

• Kim Min

  Natural Products Res. Center Korea Inst. Of Sci. And Technol. (kist)

• Kwon Oh-Wook

  Graduate School of East-West Medical Science, Kyung Hee University

• Park Jin-Soo

  Natural Medicine Center, Korea Institute of Science and Technology (KIST), Gangneung

• Kwon Hak

  Natural Medicine Center, Korea Institute of Science and Technology (KIST), Gangneung

• Kim Sun

  Department of Pharmacy, Gachon University

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