Sanjoinine A Isolated from Zizyphi Spinosi Semen Augments Pentobarbital-Induced Sleeping Behaviors through the Modification of GABA-ergic Systems(Pharmacology)

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概要

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• Zizyphi Spinosi Semen (ZSS) has been widely used for the treatment of insomnia in oriental countries. This experiment was performed to investigate whether sanjoinine A, one of major alkaloid compounds of ZSS, has hypnotic effects and/or enhances pentobarbital-induced sleeping behaviors through the γ-aminobutyric acid (GABA)-ergic systems. Sanjoinine A itself did not induce sleeping at the higher dose used in this experiment. However, sanjoinine A prolonged sleeping time and reduced the sleeping latency induced by pentobarbital in a dose-dependent manner similar to muscimol, a GABA_A receptor agonist. Sanjoinine A also increased sleeping rate and sleeping time when administered combined with pentobarbital at a sub-hypnotic dosage and showed synergistic effects with muscimol in potentiating sleeping onset and enhancing sleeping time induced by pentobarbital. In addition, both sanjoinine A and pentobarbital increased chloride influx in primary cultured cerebellar granule cells. Sanjoinine A also showed similar effects with muscimol in potentiating chloride influx inducing effects of low dose pentobarbital. Sanjoinine A decreased GABA_A receptor α-subunit expression and increased γ-subunit expression, and had no effects on the abundance of β-subunits in primary cultured cerebellar granule cells, showing different subunit expression from pentobarbital. In addition, we found that sanjoinine A also enhanced expression of glutamic acid decarboxylase (GAD), but pentobarbital did not. In conclusion, sanjoinine A itself does not induce sleeping, but it augments pentobarbital-induced sleeping behaviors through the modification of GABA-ergic systems.

• 公益社団法人日本薬学会の論文
• 2007-09-01

著者

• Oh Ki-wan

  College Of Pharmacy Chunghuk National University

• Oh Ki-wan

  College Of Pharmacy Chungbuk National University

• EUN Jae

  College of Pharmacy, Woosuk University

• MA Yuan

  Research Institute of Veterinary Medicine, Chungbuk National University

• HONG Jin-Tae

  College of Pharmacy, Chunghuk National University

• Hong Jin

  Coll. Of Pharmacy Chungbuk National Univ. Kor

• Hong Jin-tae

  College Of Pharmacy Chunghuk National University

• Hwang Ji-hye

  College Of Pharmacy Cbitrc Chungbuk National University

• Ma Yuan

  Research Institute Of Veterinary Medicine Chungbuk National University

• HAN Huishan

  College of Pharmacy, Chungbuk National University

• KIM Hyung-Chun

  College ege of Pharmacy, Kangwon National University

• Hong Jin

  College Of Pharmacy And Cbitrc Chungbuk National University

• Han Huishan

  College Of Pharmacy Chungbuk National University

• Eun Jae

  College Of Pharmacy Woosuk University

• Kim Hyung-chun

  College Ege Of Pharmacy Kangwon National University

• Hong Jin-tae

  College Of Pharmacy Cbitrc College Of Pharmacy And Medical Research Center Chungbuk National Univers

• Hong Jin-Tae

  College of Pharmacy and Medical Research Center, Chungbuk National University

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