Anti-neuroinflammatory Activity of Kamebakaurin From Isodon japonicus via Inhibition of c-Jun NH2-Terminal Kinase and p38 Mitogen-Activated Protein Kinase Pathway in Activated Microglial Cells

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概要

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• Compelling evidence supports the notion that the majority of neurodegenerative diseases are associated with microglia-mediated neuroinflammation. Therefore, quelling of microglial activation may lead to neuronal cell survival. The present study investigated the effects of Kamebakaurin (KMBK), a kaurane diterpene isolated from Isodon japonicus HARA (Labiatae), on the production of pro-inflammatory mediators in lipopolysaccharide (LPS)-stimulated cytotoxicity in rat primary microglial cultures and the BV-2 cell line. KMBK significantly inhibited the LPS-induced production of nitric oxide (NO) in a concentration-dependent fashion in activated microglial cells. The mRNA and protein levels of inducible nitric oxide synthase (iNOS) and cyclooxycenase-2 (COX-2) were also decreased dose-dependently. Furthermore KMBK inhibited the JNK and p38 mitogen-activated protein kinases (MAPKs) in LPS-stimulated BV-2 microglial cells. Considering the results obtained, the present study authenticated the potential benefits of KMBK as a therapeutic target in ameliorating microglia-mediated neuroinflammatory diseases.

• 社団法人 日本薬理学会の論文

著者

• Kim In

  Department Of Animal Resource And Sciences Dankook University

• Hwang Bang-yeon

  College Of Pharmacy Research Center For Bioresource And Health Chungbuk National University

• Kim Byung-Wook

  Department of Biotechnology, Konkuk University, Korea

• Koppula Sushruta

  Department of Biotechnology, Konkuk University, Korea

• Lim Hyung-Woo

  Department of Biotechnology, Konkuk University, Korea

• Hong Sun-Min

  Department of Biotechnology, Konkuk University, Korea

• Han Sang-Don

  Department of Neurology, School of Medicine, Konkuk University, Korea

• Choi Dong-Kug

  Department of Biotechnology, Konkuk University, Korea

• Hong Sun-min

  Department Of Biotechnology Konkuk University

• Lim Hyung-woo

  Department Of Biotechnology Konkuk University

• Hwang Bang-yeon

  College Of Pharmacy And Medical Research Center (cict) Chungbuk National University

• Choi Dong-kug

  Department Of Biotechnology Konkuk University

• Han Sang-don

  Department Of Neurology School Of Medicine Konkuk University

• Kim Byung-wook

  Department Of Biotechnology Konkuk University

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