MMHD [(S,E)-2-Methyl-1-(2-methylthiazol-4-yl) hexa-1,5-dien-ol], a Novel Synthetic Compound Derived From Epothilone, Suppresses Nuclear Factor-κB–Mediated Cytokine Expression in Lipopolysaccharide-Stimulated BV-2 Microglia

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概要

• 論文の詳細を見る

• The effects of MMHD [(S,E)-2-methyl-1-(2-methylthiazol-4-yl) hexa-1,5-dien-ol], a novel synthetic compound derived from epothilone, was investigated for its effects on the expression of proinflammatory mediators in lipopolysaccharide-stimulated BV-2 microglia. MMHD attenuated the expressions of inducible nitric oxide synthase and cyclooxygenase-2 mRNA and protein without affecting cell viability. Moreover, MMHD suppressed nuclear factor-κB (NF-κB) activation via the translocation of p65 into the nucleus. These results indicate that MMHD exerts anti-inflammatory properties by suppressing the transcription of proinflammatory cytokine genes through the NF-κB signaling pathway.

• 社団法人 日本薬理学会の論文

著者

• Kim Byung-Wook

  Department of Biotechnology, Konkuk University, Korea

• Koppula Sushruta

  Department of Biotechnology, Konkuk University, Korea

• Choi Dong-Kug

  Department of Biotechnology, Konkuk University, Korea

• Jeon Na-Ra

  Department of Biotechnology, Konkuk University, Korea

• Park Su-Ho

  Department of Chemistry, Chungbuk National University, Korea

• Lee Hyo-Won

  Department of Chemistry, Chungbuk National University, Korea

• Lee Hyo-won

  Department Of Chemistry Chungbuk National University

• Park Su-ho

  Department Of Chemistry Chungbuk National University

• Choi Dong-kug

  Department Of Biotechnology Konkuk University

• Jeon Na-ra

  Department Of Biotechnology Konkuk University

• Kim Byung-wook

  Department Of Biotechnology Konkuk University

• Koppula Sushruta

  Department Of Biotechnology Konkuk University

関連論文

• Anti-neuroinflammatory Activity of Kamebakaurin From Isodon japonicus via Inhibition of c-Jun NH2-Terminal Kinase and p38 Mitogen-Activated Protein Kinase Pathway in Activated Microglial Cells
• MMHD [(S,E)-2-Methyl-1-(2-methylthiazol-4-yl) hexa-1,5-dien-ol], a Novel Synthetic Compound Derived From Epothilone, Suppresses Nuclear Factor-κB–Mediated Cytokine Expression in Lipopolysaccharide-Stimulated BV-2 Microglia
• MMHD [(S,E)-2-Methyl-1-(2-methylthiazol-4-yl) hexa-1,5-dien-ol], a Novel Synthetic Compound Derived From Epothilone, Suppresses Nuclear Factor-κB-Mediated Cytokine Expression in Lipopolysaccharide-Stimulated BV-2 Microglia
• Anti-neuroinflammatory Activity of Kamebakaurin From Isodon japonicus via Inhibition of c-Jun NH_2-Terminal Kinase and p38 Mitogen-Activated Protein Kinase Pathway in Activated Microglial Cells
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