Reduction by a model of NAD(P)H. XIV. Mechanistic consideration on the role of metal ion.
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概要
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The driving force for the catalytic activity of metal ions on the reduction of α-keto esters with an NAD(P)H-model compound has been discussed. The scope of the reaction and spectroscopic investigations as well as molecular orbital consideration have revealed that the transition state of the reaction consists of a ternary complex in analogy with a coenzyme–enzye–substrate complex in an enzymic system. It is concluded that, at the transition state, one electron migrates from a model compound to a substrate through a metal ion, which is followed by the transfer of a proton.
- 公益社団法人 日本化学会の論文
著者
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Ohno Atsuyoshi
Institute For Chemical Research Kyoto Univ.
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Oka Shinzaburo
Institute For Chemical Research Kyoto University
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Yamamoto Hiroyuki
Institute Of High Polymer Research Faculty Of Textile Science And Technology Shinshu University
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Kim Seung
Institute for Chemical Research, Kyoto University
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Kimura Takahide
Institute for Chemical Research, Kyoto University
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Ohnishi Yutaka
Sagami Chemical Research Center
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Yamamoto Hiroyuki
Institute for Chemical Research, Kyoto University
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