Stereochemical control in microbial reduction. 12. (S)-4-nitro-2-butanol as a source to synthesize natural products.
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概要
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(<I>S</I>)-(+)-4-Nitro-2-butanol (<B>1</B>) obtained by the stereoselective reduction of 4-nitro-2-butanone by bakers' yeast was employed for the syntheses of natural products. A precursor of (+)-brefeldin A is synthesized starting from this chiral building block by 10 steps short-cut procedure compared with the shortest method so far reported. (<I>S</I>)-(+)-Sulcatol is obtained in much better enantiomeric purity than those reported. The reactivity of <B>1</B> in base-catalyzed condensations with Michael acceptors or aldehydes is largely affected by a base employed as the catalyst.
- 公益社団法人 日本化学会の論文
著者
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Ohno Atsuyoshi
Institute For Chemical Research Kyoto Univ.
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Kitayama Takashi
Institute For Chemical Research Kyoto University
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Nakamura Kaoru
Institute For Chemical Research Kyoto University
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Inoue Yoshihiko
Institute For Chemical Research Kyoto University
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KITAYAMA Takashi
Institute for Chemical Research, Kyoto University
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