Stereochemistry of NAD(P)-coenzyme in the reaction catalyzed by glycerol dehydrogenase.
スポンサーリンク
概要
- 論文の詳細を見る
The coenzyme stereospecificities in the reaction of glycerol dehydrogenases (GDH) from various microbial sources have been determined. It is found that the nicotinamide-coenzymes (NADH and NADPH) employed by GDHs from eucaryotes exert the <I>pro-S</I> specificity, whereas those employed by procaryotes exert the <I>pro-R</I> specificity. The stereospecificity of the coenzyme seems to have a correlation with chemical evolution of GDH as well as biological evolution of the host organism.
- 公益社団法人 日本化学会の論文
著者
-
Ohno Atsuyoshi
Institute For Chemical Research Kyoto Univ.
-
Nakamura Kaoru
Institute For Chemical Research Kyoto University
-
Miyai Takehiko
Institute For Chemical Research Kyoto University
-
Shiraga Tsuyoshi
Institute for Chemical Research, Kyoto University
関連論文
- Further Characterization of Earthworm Serine Proteases : Cleavage Specificity Against Peptide Substrates and on Autolysis
- Multi-enzymatic Glucosylation Using Eucalyptus UDP-Glucosyltransferase Coupled UDPglucose-Fermentation by Bakers'Yeast
- Asymmetric Reduction of α-Keto Esters and α-Diketones with a Bakers' Yeast Keto Ester Reductase
- Lipase-catalyzed Synthesis of Arbutin Cinnamate in an Organic Solvent and Application of Transesterification to Stabilize Plant Pigments
- Preparation of Optically Active α-Hydroxy Esters : Stereoselective Reduction of α-Keto Esters Using Thermophilic Actinomycetes
- Amino Acid Sequence and Characterization of Aldo-keto Reductase from Bakers' Yeast
- Stereoselective Reduction of α- and β-Keto Esters with Aerobic Thermophiles, Bacillus Strains
- Protein Sequences of Two Keto Ester Reductases: Possible Identity as Hypothetical Proteins
- Enzymatic Production of (S)-1-Acetoxy-2-Alkanol with Bakers' Yeast Cell-Free Extract in a Membrane Reactor
- Purification and Characterization of α-Keto Ester Reductases from Bakers' Yeast
- Differences in Protein Structure and Similarities in Catalytic Function of Two L-Stereoselective Carbonyl Reductases from Bakers' Yeast
- Reactivities of Stable Rotamers. XLI. Reactions of 1-(9-Fluorenyl)-2-(1-methylethenyl)naphthalene Rotamers with Chalcogenyl Halides and Observation of Coloration During the Reaction of Methanesulfenyl Chloride and the ap-Rotamer
- Detoxifying Effect of Desalinated Deep Seawater on Organotin-poisoned Euglena gracilis(Food & Nutrition Science)
- Detoxification Effect of Iron-encaging Zeolite-processed Water in Tributyltin-intoxicated Euglena gracilis Z
- Effect of Several Solutions Including Mineral-encaging Zeolites on the Restoration of Cell Motility of Tributyltin-intoxicated Euglena gracilis Z
- First Principles Calculations of Vacancy Formation Energies in *13 Pyramidal Twin Grain Boundary of α-Al_2O_3
- Stereochemical Control in Microbial Reduction. 30. Reduction of Alkyl 2-Oxo-4-phenylbutyrate as Precursors of Angiotensin Converting Enzyme (ACE) Inhibitors
- The NADPH : Quinone Oxidoreductase P1-ζ-crystallin in Arabidopsis Catalyzes the α, β-Hydrogenation of 2-Alkenals : Detoxication of the Lipid Peroxide-Derived Reactive Aldehdes
- Conformational Effect (Induced-Fit) on Catalytic Activity of α-Chymotrypsin
- Stereochemical Control in Microbial Reduction. XXIX. Mechanism of Stereochemical Control with an Additive in the Diastereoselective Reduction by Geotrichum candidum
- Stereochemical Control in Microbial Reduction. XXV. Additives Controlling Diastereoselectivity in a Microbial Reduction of Ethyl 2-Methyl-3-oxobutanoate
- Stereoselective Preparation of (R)-4-Nitro-2-butanol and (R)-5-Nitro-2-pentanol Mediated by a Lipase(Organic Chemistry)
- Rate Enhancement of Lipase-catalyzed Reaction in Supercritical Carbon Dioxide
- PB124 DIASTEREOSELECTIVE SYNTHESIS OF 2-ALKYL-3-HYDROXYBUTANOATES, USEFUL CHIRAL SYNTHONS, BY MICROBES
- Irreversibility of Single Electron Transfer Occurring from Trivalent Phosphorus Compounds to Iron (III) Complexes in the Presence of Ethanol
- Reaction of Trivalent Phosphorus Compounds with an Fe (III) Complex in the Presence of Alcohol. Single Electron Transfer Accompanied by a P-O Bond Formation
- Stereoelectronic Effects on the One-Electron Donor Reactivity of Trivalent Phosphorus Compounds. Experimental and Theoretical Investigations
- Stereochemical Control in Microbial Reduction. XXVIII. Asymmetric Reduction of α,β-Unsaturated Ketones with Bakers' Yeast
- NAD(P)^+-NAD(P)H Models. 87. Nonsteric Stereochemistry Controlled by a Carbonyl Dipole
- NAD(P)^+-NAD(P)H Models. 86. Nonsteric Stereochemistry in Hydride-Transfer to Sulfinylpyridinium Ion
- Reactivity of Cation Radicals Generated from Trivalent-Phosphorus Compounds in the Reaction with Methylviologen: Kinetic Analysis
- Stereospecific Electrochemical Oxidation of NAD(P)H Analogs Mediated by Radical Cation of Anilines
- Asymmetric Reduction of Butyl Pyruvate Catalyzed by Immobilized Glycerol Dehydrogenase in Organic-Aqueous Biphasic Media
- The Catalytic Role of Iodide Ion / Iodine Couple in the Photo-Reduction of 10-Methylacridinium Ion with Diphenylphosphine Oxide
- PB23 NAD(P)H MODELS-A HIGHLY SELECTIVE REDUCING REAGENTS IN ORGANIC SYNTHESIS
- Novel Reaction of Selenobenzophenones with Alkyllithiums Leading to Symmetrical Olefins
- Exalted Resonance Effect in the Aryl-Assisted Solvolyses of 2-Aryl-2-(trifluoromethyl)ethyl m-Nitrobenzenesulfonates
- Stereoselection without Steric Effect but Controlled by Electronic Effect : Important Contribution of Ground State
- Lipase-Catalyzed Transesterification of Aryl-Substituted Alkanols in an Organic Solvent
- Stereoselective Synthesis of (±)-Isonitramine and (±)-Sibirine
- NAD(P)H-NAD(P)+models. 74. Entropy-controlled kinetics, stereochemistry, and tunneling effect.
- NAD(P)+-NAD(P)H models. 71. A convenient route to the synthesis of juvabione.
- Reduction by a model of NAD(P)H. XIV. Mechanistic consideration on the role of metal ion.
- A new, highly efficient, and simple procedure for the construction of medium-sized nitrogen heterocyclic ring system.
- Charge-transfer intermediate in the reaction of thioketone with nucleophiles.
- NAD(P)+-NAD(P)H models. 65. Photochemical reductive desulfonylation of .BETA.-keto sulfones with Hantzsch ester.
- NAD(P)+-NAD(P)H models. 59 1,2- Versus 1,4-reduction of .BETA.,.GAMMA.-unsaturated .ALPHA.-keto ester.
- Stereochemical control in microbial reduction. Part 7. Enantioselective reduction of 2-methyl-3-oxopropionate by bakers' yeast.
- Determination of the configuration of diastereoisomers of 2-alkyl-3-hydroxybutanoates with gas chromatography.
- NAD(P)+-NAD(P)H model. 54. Free radical mechanism for the reductive debromination of vic-dibromides to alkenes.
- Stereochemical control in microbial reduction. 12. (S)-4-nitro-2-butanol as a source to synthesize natural products.
- Reduction by a model of NAD(P)H. 34. Substituent effect on asymmetric reduction of trifluoroacetophenones.
- Reduction by a model of NAD(P)H. 32. Stereoselective reduction of camphoroquinone by a chiral NAD(P)H model.
- Enhanced enantioselectivity of the lipase-catalyzed hydrolysis by the addition of a catalytic amount of an amino alcohol.
- NAD(P)+-NAD(P)H models. 72. Isotope effects to prove the multi-step mechanism in the reduction with an NAD(P)H analog.
- NAD(P)H-NAD(P)+models. 73. Structure-stereochemistry relationship in the reaction of NAD analog.
- Reduction by a model of NAD(P)H. 35. Spectroscopic detection of charge-transfer intermediate.
- Stereochemistry of NAD(P)-coenzyme in the reaction catalyzed by glycerol dehydrogenase.
- Stereochemical control in microbial reduction. XV. Preparation of (2R, 3S)-2-allyl-3-hydroxybutanoate.
- NAD(P)+-NAD(P)H model. 63. Regioselective reduction of dienoic ketones and aldehydes with an NAD(P)H model on silica gel.
- Stereochemical control in microbial reduction. 8. Stereochemical control in microbial reduction of .BETA.-keto esters.
- Stereochemical control in microbial reduction. 9. Diastereoselective reduction of 2-alkyl-3-oxobutanoate with bakers' yeast.
- A kinetic study of the reaction of 1-propyl-1,4-dihydronicotinamide with hexacyanoferrate(III).
- Reduction by a model of NAD(P)H. 36. First and direct evidence for the multi-step mechanism.
- Reaction of electrochemically generated radical anion of thioketone with alkylating agents.
- Stereochemical Control in Microbial Reduction. 18. Mechanism of Stereochemical Control in the Diastereoselective Reduction with Bakers' Yeast.