Stereochemical control in microbial reduction. Part 7. Enantioselective reduction of 2-methyl-3-oxopropionate by bakers' yeast.
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概要
- 論文の詳細を見る
Various esters of 2-methyl-3-oxopropionic acid were subjected to the reduction with bakers' yeast. Effects of size and bulkiness as well as hydrophobicity of alcohol moieties of the substrates on the enantioselectivity of the reduction were investigated. The substrates having bulky ester groups gave the (<I>R</I>)-hydroxy esters with high enantioselectivities. A mechanism to alter the stereoselectivity of the reduction is proposed.
- 公益社団法人 日本化学会の論文
著者
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Ohno Atsuyoshi
Institute For Chemical Research Kyoto Univ.
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Nakamura Kaoru
Institute For Chemical Research Kyoto University
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Ushio Kazutoshi
Institute For Chemical Research Kyoto University
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Oka Shinzaburo
Institute For Chemical Research Kyoto University
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Miyai Takehiko
Institute For Chemical Research Kyoto University
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Ushio Kazutoshi
Institute for Chemical Research, Kyoto University
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