Microbiological Quality Assessment of Laboratory Mice in Korea and Recommendations for Quality Improvement

スポンサーリンク

概要

• 論文の詳細を見る

• Regular monitoring of commercial laboratory rodents and institutional research animal residents is essential for microbiological quality control programs. The objective of our study was to investigate the recent prevalence of infectious pathogens in laboratory mice from eight experimental animal vendors and 56 institutional animal facilities in Korea. Our investigation was conducted in 2006-2007. Specific Pathogen Free (SPF) mice from four commercial breeders were clean according to serological, bacteriological, parasitological, and histopathological examination results. However, mice from one intermediate vendor that distributed SPF animals from main commercial vendors to local districts had Syphacia obvelata and Mycoptes musculinus infections. Additionally, mice from conventional animal breeders were highly contaminated. Among the 56 institutional animal facilities, mouse hepatitis virus (MHV), Sendai virus and Mycoplasma pulmonis positive results were obtained in 23.2, 8.9, and 1.8% of animals tested, respectively. These results indicate that quarantine and eradication efforts of infectious pathogens in these facilities are sub-optimal and need to be improved. The use of commercial conventional mice for research should be eliminated and appropriate vendor selection as well as thorough quarantine before releasing animals into a facility are needed. Finally we suggest qualified veterinary experts are needed at each animal facility to ensure an adequate health surveillance program.

• 社団法人　日本実験動物学会の論文

著者

• PARK Jae-Hak

  Department of Laboratory Animal Medicine

• BAEK Min-Won

  Department of Laboratory Animal Medicine, College of Veterinary Medicine and School of Agricultural

• LEE Hui-Young

  Department of Laboratory Animal Medicine, College of Veterinary Medicine and School of Agricultural

• KIM Dong-Jae

  Department of Laboratory Animal Medicine, College of Veterinary Medicine and School of Agricultural

• Na Yi-Rang

  Department of Laboratory Animal Medicine, College of Veterinary Medicine and KRF Zoonotic Disease Pr

• Seok Seung-Hyeok

  Institute for Experimental Animals, College of Medicine, Seoul National University

• PARK Sung-Hoon

  Department of Laboratory Animal Medicine, College of Veterinary Medicine and KRF Zoonotic Disease Pr

• LEE Hyun-Kyoung

  Department of Laboratory Animal Medicine, College of Veterinary Medicine and KRF Zoonotic Disease Pr

• Na Yi-rang

  Department Of Laboratory Animal Medicine College Of Veterinary Medicine

関連論文

• 圧電膜で駆動する磁気光学SLMの作製と特性
• スパッタエピタキシャル成長ガーネット膜のマイクロパターニング
• 選択的エピタキシャル成長ガーネット膜を利用した磁気光学SLM
• 電圧駆動型磁気光学SLMの開発
• 3次元光クロスコネクト装置の開発
• 低電圧駆動型磁気光学空間光変調器の開発
• 羊顎関節の実験的骨関節症におけるヒアルロン酸の治療効果
• 磁気光学効果を用いた空間光変調器のピクセルグルーブ深さの効果
• Microbiological Monitoring of Guinea Pigs Reared Conventionally at Two Breeding Facilities in Korea
• Differential Identification of Mycoplasma pulmonis and M. arthritidis Using PCR-Based RFLP
• 韓国におけるコイ(Cyprinus carpio)のエピテリオシスチス(短報)(病理学)
• β-Naphthoflavone Caused Up-Regulation of AhR Regulated GFP in Transgenic Zebrafish
• Microbiological Quality Assessment of Laboratory Mice in Korea and Recommendations for Quality Improvement
• Purification and Characterization of a Novel Fibrinolytic Enzyme from Bacillus sp. KA38 Originated from Fermented Fish
• Zeaxanthin Dipalmitate from Lycium chinense Fruit Reduces Experimentally Induced Hepatic Fibrosis in Rats
• Development of a Xenoestrogen-Responsive Transient Zebrafish (Danio rerio) Using the Brain Aromatase based Reporter Gene
• Validation of porcine corneal opacity and permeability assay as an alternative to eye irritation tests
• 磁気光学効果を用いた空間光変調器
• Zebrafish embryo proteins promote sphere-forming abilities of human melanoma cell line
• International evaluation of bovine corneal opacity and permeability assay as an alternative method to eye irritant test
• (+)-α-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase
• Magnetooptic Spatial Light Modulator Array Fabricated by IR Annealing
• らせん菌の感染と豚の胃炎の関連
• ファージ発現系リコンビナント抗体を用いた豚流行性下痢ウイルスの免疫組織化学的検出(短報)
• Modulation of Substrate Preference of Thermus Maltogenic Amylase by Mutation of the Residues at the Interface of a Dimer
• Cre/IoxP-regulated transgenic zebrafish model for neural progenitor-specific oncogenic Kras expression
• Bone morphogenetic protein 7 induces mesenchymal-to-epithelial transition in melanoma cells, leading to inhibition of metastasis
• Zebrafish embryo extracts promote sphere-forming abilities of human melanoma cell line
• CATARRHAL PROVENTRICULITIS ASSOCIATED WITH A FILAMENTOUS ORGANISM IN PET BIRDS
• Comparative Pathological Studies in Liver Cirrhosis Model of Rat
• Prevalence of Murine Norovirus Infection in Korean Laboratory Animal Facilities
• Microbiological Quality Assessment of Laboratory Mice in Korea and Recommendations for Quality Improvement
• Modulation of Substrate Preference of Thermus Maltogenic Amylase by Mutation of the Residues at the Interface of a Dimer
• DISSEMINATED INTRAVASCULAR COAGULATION (DIC) IN RABBIT HAEMORRHAGIC DISEASE

もっと見る 閉じる

スポンサーリンク