Prevalence of Murine Norovirus Infection in Korean Laboratory Animal Facilities

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概要

• 論文の詳細を見る

• Currently, murine noroviruses (MNV) are the most prevalent viral pathogens identified in laboratory animal facilities. While several reports exist concerning the prevalence of MNV in North American research facilities, very few reports are available for other parts of the world, including Korea. This study evaluated the prevalence of MNV infection in 745 murine sera collected from 15 animal facilities in Korea by enzyme linked immunosorbent assay (ELISA). Positive cases were subcategorized by murine strain/genetics, housing environments, and animal sources. In summary, 6.6% of inbred/outbred mice purchased from commercial vendors were seropositive, 9.6% of in-house colonies were seropositive, and 27.0% of genetically modified mice (GMM) were seropositive. Partial gene amplification of fecal isolates from infected animals had homologous (100%) with MNV-4.

著者

• Park Jae-hak

  Department Of Comparative Pathology Faculty Of Veterinary Medicine Hokkaido University

• HAN Ju-hee

  Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University

• Chung Doo

  Biomedical Physics Lab. School Of Physics Seoul National University

• Kim Tae-hyun

  Department Of Dermatology Yonsei University Wonju College Of Medicine

• Kim Dong

  Department Of Anatomy School Of Medicine Kyungpook National University

• Na Yi-rang

  Department Of Laboratory Animal Medicine College Of Veterinary Medicine

• Han Ju-hee

  Department Of Laboratory Animal Medicine College Of Veterinary Medicine

• Baek Min-won

  Department Of Laboratory Animal Medicine College Of Veterinary Medicine And Krf Zoonotic Disease Pri

• Kim Jong

  Department Of Agricultural Bio-resources National Academy Of Agricultural Science Rural Development

• NA Yi-Rang

  Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University

• SEOK Seung

  Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University

• TURNER Patricia

  Department of Pathology, Ontario Veterinary College, University of Guelph

• KANG Byeong-Cheol

  Biomedical Research Institute, Seoul National University Hospital

• KIM Tae-Hyun

  Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University

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