Preparation of Bupleurum Nasal Spray and Evaluation on Its Safety and Efficacy
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概要
- 論文の詳細を見る
Radix Bupleuri is widely used in traditional medicine for the treatment of fever, pain, and inflammation associated with influenza or the common cold. The essential oil extracted from the herb is generally claimed to play the major role in the efficacious treatment of fever. The purpose of the present study was to formulate an intranasal delivery system for the essential oil in an aqueous solution used in the form of nasal spray. From 450g Radix Bupleuri was extracted the essential oil in the amount of about 0.2ml, which was slightly water-soluble and viscous with low-fluidity. In order to dissolve the essential oil evenly in the aqueous solution, tween-80 (TW-80, used in 10% (w/v) solution), propylene glycol (PG) and diethylene glycol monoethyl ether (TC) were selected as the favorable solubilizing agents, whose amount was respectively determined by L_<16> (4^5) orthogonal design. An aqueous solution with clarity and no ciliotoxicity was prepared when TW-80 8% (v/v), PG 14.4% (v/v) and TC 14.4% (v/v) were added. Employed to evaluate the acute toxicity, the rats grew well and were kept active and healthy within 14 d after an intranasal administration of this preparation at the dose of oil from 10g Bupleuri/kg (50-fold higher than the clinical dose), indicating that there would be no serious toxicity at the normal dose. Intranasal administration of this preparation to 2kg rabbits with fever induced by subcutaneous injection of turpentine decreased body temperature markedly (0.5, 0.8 and 1.0℃ respectively at the dose of oil from 1, 2 and 4g Bupleuri/body). In addition, the administration significantly reduced fever in 200g rats induced by intramuscular injection of colicine suspension (0.6℃ at the dose of oil from 0.8g Bupleuri/body). The results suggest that the formulation of nasal spray for the essential oil from Radix Bupleuri can be potentially effective in the treatment of fever.
- 公益社団法人日本薬学会の論文
- 2006-01-01
著者
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Lu Wei
Department Of Computer Science And Engineering Shanghai Jiao Tong University
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YIN Ming
Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang Universi
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Yin Ming
Department Of Pharmacology School Of Pharmacy Shanghai Jiaotong University
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Yin Ming
Department Of Applied Chemistry And Biotechnology Faculty Of Engineering Yamanashi University
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XIE Yueling
Department of Pharmaceutics, School of Pharmacy, Fudan University
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CAO Shilei
Department of Pharmaceutics, School of Pharmacy, Fudan University
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JIANG Xinguo
Department of Pharmaceutics, School of Pharmacy, Fudan University
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TANG Wenlu
Department of Pharmacology, School of Pharmacy, Shanghai Jiaotong University
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Tang Wenlu
Department Of Pharmacology School Of Pharmacy Shanghai Jiaotong University
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Xie Yueling
Department Of Pharmaceutics School Of Pharmacy Fudan University
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Cao Shilei
Department Of Pharmaceutics School Of Pharmacy Fudan University
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Jiang Xinguo
Department Of Pharmaceutics School Of Pharmacy Fudan University
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Lu Wei
Department Of Pharmaceutics School Of Pharmacy Fudan University
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Lu Wei
The State Key Lab. Of Natural And Biomimetic Drugs Peking Univ.
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