The Additive Effects of Minoxidil and Retinol on Human Hair Growth in Vitro(Molecular and Cell Biology)
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概要
- 論文の詳細を見る
Minoxidil enhances hair growth by prolonging the anagen phase and induces new hair growth in androgenetic alopecia (AGA), whereas retinol significantly improves scalp skin condition and promotes hair growth. We investigated the combined effects of minoxidil and retinol on human hair growth in vitro and on cultured human dermal papilla cells (DPCs) and epidermal keratinocytes (HaCaT). The combination of minoxidil and retinol additively promoted hair growth in hair follicle organ cultures. In addition, minoxidil plus retinol more effectively elevated phosphorylated Erk, phosphorylated Akt levels, and the Bcl-2/Bax ratio than minoxidil alone in DPCs and HaCaT. We found that the significant hair shaft elongation demonstrated after minoxidil plus retinol treatment would depend on the dual kinetics associated with the activations of Erk- and Akt-dependent pathways and the prevention of apoptosis by increasing the Bcl-2/Bax ratio.
- 社団法人日本薬学会の論文
- 2007-01-01
著者
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Kim Kyu
Department of Science Education, Ewha Womans University
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Kim K
Department Of Dermatology Seoul National University College Of Medicine Laboratory Of Cutaneous Agin
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Cho Kwang
Department Of Dermatology Seoul National University College Of Medicine Laboratory Of Cutaneous Agin
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LEE Seung
Department of Dermatology and Human Barrier Research Institute, Yonsei University College of Medicin
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KWON Oh
Department of Chemical Engineering, Hongik University
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Kwon Oh
Department Of Dermatology Seoul National University College Of Medicine
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EUN Hee
Department of Dermatology, Seoul National University College of Medicine
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Yoo Hyeon
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Ag
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CHANG In-Young
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Ag
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Pyo Hyun
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Ag
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KANG Yong
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Ag
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Cho Kwang
Department Of Anesthesiology And Pain Medicine Yonsei University College Of Medicine
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Kwon Oh
Department Of Anatomy College Of Medicine Chungnam National University
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Eun Hee
Department Of Dermatology Seoul National University College Of Medicine
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Eun Hee
Department Of Dermatology And Artificial Organ Laboratory Of Clinical Research Institute Seoul Natio
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Kim Kyu
Department Of Dermatology Clinical Research Institute Seoul National University Hospital College Of
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Pyo Hyun
Department Of Dermatology Seoul National University College Of Medicine Laboratory Of Cutaneous Agin
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Yoo Hyeon
Department Of Dermatology Seoul National University College Of Medicine Laboratory Of Cutaneous Agin
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Lee Seung
Department Of Dermatology Seoul National University College Of Medicine Laboratory Of Cutaneous Agin
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Chang In-young
Department Of Dermatology Seoul National University College Of Medicine Laboratory Of Cutaneous Agin
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Kang Yong
Department Of Dermatology Seoul National University College Of Medicine
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Lee Seung
Department Of Anesthesiology And Pain Medicine Dong-a University Hospital
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Yoo Hyeon
Department Of Dermatology Seoul National University College Of Medicine
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Lee Sun-mee
College Of Pharmacy Yeungnam University
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Kang Yong
Department Of Chemical And Biological Engineering Korea University
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Kang Yong
Department Of Anatomy
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Kwon Oh
Department Of Aerospace Engineering Kaist
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Kim Kyu
Department of Applied Physics and Electronics, Sangji Univeristy, Wonju, Gangwon 220-702, Korea
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