Effect of Chitosan Oligosaccharide on 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Oxidative Stress in Mice

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概要

• 論文の詳細を見る

• The abilities of two types of chitosan oligosaccharides, chitosan oligosaccharide I (1-kDa<MW<3-kDa) and chitosan oligosaccharide II (3-kDa<MW<5-kDa), to prevent 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative stress were examined in ICR mice. Chitosan oligosaccharide I had no effect on TCDD-induced alterations in lipid peroxidation and glutathione S-transferase activity or liver weight change. However, mice treated with chitosan oligosaccharide II were protected from TCDD-induced lipid peroxidation, inhibition of glutathione peroxidase and glutathione S-transferase activities, and losses in body and liver weights. These results suggest that chitosan oligosaccharide might be a potential agent for combating TCDD-induced pathogenesis.

• 公益社団法人日本薬学会の論文
• 2002-09-01

著者

• Chang Hyeun

  Department Of Pharmacy College Of Pharmacy Yeungnam University

• NAM Kyung-Soo

  Department of Pharmacology, College of Medicine, Dongguk University

• Nam Kyung-soo

  Department Of Pharmacology College Of Medicine And Intractable Disease Research Center Dongguk Unive

• SHON Yun-Hee

  Department of Pharmacology, College of Medicine and Intractable Disease Research Center, Dongguk Uni

• PARK In-Kook

  Department of Biology, College of Science, Dongguk University

• MOON Il-Soo

  Department of Anatomy College of Medicine, Dongguk University

• PARK In-Kyung

  Department of Food Science and Technology, College of Natural Sciences, Catholic University of Daegu

• Moon Il-soo

  Department Of Anatomy College Of Medicine Dongguk University

• Park In-kook

  Department Of Biology College Of Science Dongguk University

• Shon Yun-hee

  Department Of Pharmacology College Of Medicine And Intractable Disease Research Center Dongguk Unive

• Nam Kyung-soo

  Department Of Pharmacology College Of Medicine And Intractable Disease Research Center Dongguk Unive

• Shon Yun-hee

  Department Of Pharmacology College Of Medicine And Intractable Disease Research Center Dongguk Unive

関連論文

• Expression of Cyclooxygenase-2 and Pro-inflammatory Cytokines Induced by 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) in Human Mast Cells Requires NF-κB Activation
• Effect of Herbal Medicines on Cytokine-Induced Cytotoxicity and Major Histocompatibility Complex (MHC) Class II Antigen Expression in Rat Thyroid Cells (Pharmacognosy)
• Effect of Chitosan Oligosaccharide on 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Oxidative Stress in Mice
• Ginkgolide C Inhibits Platelet Aggregation in cAMP- and cGMP-Dependent Manner by Activating MMP-9(Pharmacognosy)
• Protective Effect of Moutan Cortex Extract on Acetaminophen-Induced Cytotoxicity in Human Chang Liver Cells
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