Flavusides A and B, Antibacterial Cerebrosides from the Marine-Derived Fungus Aspergillus flavus
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概要
- 論文の詳細を見る
Flavusides A (1) and B (2), two new antibacterial cerebroside derivatives, and the previously described phomaligol A (3), kojic acid (4), methyl kojic acid (5), and dimethyl kojic acid (6) have been isolated from the extract of a marine isolate of the fungus Aspergillus flavus. The structure and absolute stereochemistry of two cerebrosides were assigned on the basis of NMR and Tandem FAB-MS/MS experiments. Compounds 1, 2, and 3 exhibited a mild antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The minimum inhibitory concentration (MIC) values for each strain are as follows: compounds 1 and 2 showed 15.6 μg/ml for S. aureus and 31.2 μg/ml for methicillin-resistant S. aureus and multidrug-resistant S. aureus, and compound 3 exhibited 31.2 μg/ml for S. aureus and methicillin-resistant S. aureus and 62.5 μg/ml for multidrug-resistant S. aureus.
- 公益社団法人 日本薬学会の論文
著者
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Kang Jung
College Of Dentistry Pusan National University
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Son Byeng
Department Of Chemistry Pukyong National University
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Choi Hong
College Of Oriental Medicine Daegu Haany University
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Yun Keumja
Department of Chemistry, Pukyong National University
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Yang Guohua
Department of Chemistry, Pukyong National University
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Sandjo Louis
Department of Chemistry, Pukyong National University
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Leutou Alain
Department of Chemistry, Pukyong National University
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Kim Gun-Do
Department of Chemistry, Dongeui University
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Choi Hong
College of Dentistry, Pusan National University
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