Microbial Mannosidation of Bioactive Chlorogentisyl Alcohol by the Marine-Derived Fungus Chrysosporium synchronum

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概要

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• The biological transformation of the biologically active chlorogentisyl alcohol (1), isolated from the marine-derived fungus Aspergillus sp., was studied. Preparative-scale fermentation of chlorogentisyl alcohol with marine-derived fungus Chrysosporium synchronum resulted in the isolation of a new glycosidic metabolite, 1-O-(α-D-mannopyranosyl)chlorogentisyl alcohol (2). The stereostructure of the new metabolite obtained was assigned on the basis of detailed spectroscopic data analyses, chemical reaction, and chemical synthesis. Compounds 1 and 2 exhibited significant radical-scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) with IC50 values of 1.0 and 4.7 μM, respectively. The compounds 1 and 2 were more active than the positive control, L-ascorbic acid (IC50, 20.0 μM).

著者

• Choi Hong

  Department of Korean Internal Medicine, College of Oriental Medicine, Daegu Haany University

• Kang Jung

  College Of Dentistry Pusan National University

• Choi Hong

  Department Of Chemistry Dongeui University

• SON Byeng

  Department of Chemistry, Pukyong National University

• Son Byeng

  Department Of Chemistry Pukyong National University

• Yun Keumja

  Department of Chemistry, Pukyong National University

• Kondempudi Chinni

  Department of Chemistry, Pukyong National University

• CHOI Hong

  Department of Chemistry, Dongeui University

• Choi Hong

  Department of Applied Physics, Korea University, Seoul 136-713, Korea

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