Induced Production of Methyl Bromodihydroxyphenyl Acetates by the Marine-Derived Fungus Aspergillus sp.
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概要
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The addition of metal bromides (NaBr and CaBr2) during fermentation of a marine isolate of the fungus Aspergillus sp. induced production of two new brominated dihydroxyphenylacetic acid derivatives, methyl 2-(6-bromo-3,4-dihydroxyphenyl)acetate (1) and methyl 2-(2,5-dibromo-3,4-dihydroxyphenyl)acetate (2), and a known compound, 2-(3,4-dihydroxyphenyl)acetic acid (3). The structures of the two new compounds (1, 2) were assigned through the combination of spectroscopic data analyses and comparison with the spectral data of compound 3. Compounds 1–3 exhibited potent radical-scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC50 values (14.2, 12.1, 11.0 µ<span style="font-variant: small-caps;">m</span>, respectively) demonstrating greater activity than the positive control (<span style="font-variant: small-caps;">l</span>-ascorbic acid; IC50, 20.0 µ<span style="font-variant: small-caps;">m</span>).
著者
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Son Byeng
Department Of Chemistry Pukyong National University
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Yun Keumja
Department of Chemistry, Pukyong National University
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Leutou Alain
Department of Chemistry, Pukyong National University
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Kang Jung
School of Dentistry, Pusan National University
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