Free 4-Hydroxyproline Content in Serum of Bedridden Aged People Is Elevated Due to Fracture

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概要

• 論文の詳細を見る

• Hydroxyproline (Hyp) content in biologial fluids is used as a parameter of collagen catabolism, especially bone resorption. In this paper, we examined the relationship between agin and serum free 4-Hyp and proline (Pro) content using a newly introduced analytical technique which is chemiluminescence determination with electrogenerated tris (2,2'-bipyridine) ruthenium(III). Serum was collected from 50 bedridden aged people and 131 normal subjects living in Yamato-son, Amamioshima, Kagoshima. In the free 4-Hyp content of normal serum, the change in females is more gentle than that males with aging. The free 4-Hyp content of bedridden aged serum is significantly (P<0.05) elevated compared to normal aged serum. Bedridden aged females and males also show levels significantly (p<0.05) elevated in comparison to normal. These changes are due to bone resorption based on bedridden patients' atrophy. In bedridden aged people, free 4-Hyp of those with a fracture was significantly (p<0.05) elevated than in people without a fracture. No relationship between low bone density and high free 4-Hyp in serum was observed. It seems that bone resorption or bedridden atrophy may be enhanced in bedridden aged people by a fracture. In free Pro content in serum, no significant change was observed. These results show that the free 4-Hyp content in serum is useful in the clinical or biological inspection of bone resorption, especially in aged people.

• 公益社団法人日本薬学会の論文
• 2000-01-01

著者

• LI Yanmei

  Biochemistry Laboratory, College of Pharmacy, Nihon University

• KOIKE Katsuya

  Biochemistry Laboratory, College of Pharmacy, Nihon University

• Li Yanmei

  Biochemistry Laboratory College Of Pharmacy Nihon University

• Koike Katsuya

  Biochemistry Laboratory College Of Pharmacy Nihon University

• SEO Miyuki

  Yamato Clinic

• SAKURADA Ikuo

  Comet Co.,

• TEZUKA Ko

  Comet Co.,

• UCHIKAWA Kazuo

  Medical Chemistry Laboratory, College of Pharmacy, Nihon University

• Tezuka Ko

  Comet Co.

• Sakurada Ikuo

  Comet Co.

• Uchikawa K

  Medical Chemistry Laboratory College Of Pharmacy Nihon University

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• Improvement in the Turnover Rate of the Stratum Corneum in False Aged Model Rats by the Administration of Geniposidic Acid in Eucommia ulmoides OLIVER Leaf
• The Promoting Effects of Geniposidic Acid and Aucubin in Eucommia ulmoides OLIVER Leaves on Collagen Synthesis
• Free 4-Hydroxyproline Content in Serum of Bedridden Aged People Is Elevated Due to Fracture
• Sensitive Determination of Domoic Acid Using High-Performance Liquid Chromatography with Electrogenerated Tris(2, 2'-bipyridine)ruthenium(III) Chemiluminescence Detection
• Electrochemical Detection of Sugar-related Compounds Using Boron-doped Diamond Electrodes

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