INTERCALATION BEHAVIOR OF 5-FLUOROURACIL INTO Mg-Al LAYERED DOUBLE HYDROXIDE
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概要
- 論文の詳細を見る
As described in this paper, the intercalation behavior of 5-fluorouracil (5-FU) into Mg-Al layered double hydroxide (LDH) was investigated using coprecipitation and ion-exchange methods. Actually, 5-FU/LDH has been characterized using element chemical analysis, powder X-ray diffraction, FT-IR spectroscopy, thermal analysis and SEM. Intercalation of 5-FU was achieved using both methods; the amount and orientation of 5-FU intercalated differed considerably by the intercalation method and co-existed anion. The d-value of 5-FU/LDH expanded to d_<003>=0.80-1.10nm, suggesting that 5-FU was intercalated into the LDH interlayer space. Results of the thermal analysis showed that the thermal stability of 5-FU was improved by intercalation in the LDH interlayer space. We propose LDH as a good host material for storage and carriage of drugs.
- 日本粘土学会の論文
著者
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HIRAHARA Hidetoshi
Department of Applied Chemistry, Faculty of Engineering, Iwate University
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Takahashi Satoshi
Department Of Urology Sapporo Medical University School Of Medicine
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AISAWA SUMIO
Department of Frontier Materials and Function Engineering, Graduate School of Engineering, Iwate Uni
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NARITA EIICHI
Department of Frontier Materials and Function Engineering, Graduate School of Engineering, Iwate Uni
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Aisawa Sumio
Department Of Frontier Materials And Function Engineering Graduate School Of Engineering Iwate Unive
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Narita E
Department Of Frontier Materials And Function Engineering Graduate School Of Engineering Iwate Unive
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Narita Eiichi
Department Of Applied Chemistry And Molecular Science Faculty Of Engineering Iwate University
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YASUTAKE AIKO
Department of Frontier Materials and Function Engineering, Graduate School of Engineering, Iwate Uni
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KOBASHI NAOYUKI
Department of Frontier Materials and Function Engineering, Graduate School of Engineering, Iwate Uni
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Hirahara Hidetoshi
Department Of Frontier Materials And Function Engineering Graduate School Of Engineering Iwate Unive
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Takahashi Satoshi
Department Of Hematology The Institute Of Medical Science The University Of Tokyo
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Takahashi S
秋田県農林水産技術センター総合食品研究所
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Sasaki A
Facuty Of Engineering Shizuoka Univeisty
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Sasaki A
Department Of Frontier Materials And Function Engineering Graduate School Of Engineering Iwate Unive
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Yasutake Aiko
Department Of Frontier Materials And Function Engineering Graduate School Of Engineering Iwate Unive
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Kobashi Naoyuki
Department Of Frontier Materials And Function Engineering Graduate School Of Engineering Iwate Unive
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Takahashi Satoshi
Departmanets Of Immunology Graduate School Of Medical And Dental Sciences Niigata University
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