Inhibitors of Bacterial Collagenase in Rhei Rhizoma

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概要

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• A hot aqueous extract of Rhei Rhizoma had an inhibitory effect on the bacterial collagenase from Cl. histolyticum. Powdered Rhei Rhizoma was treated with organic solvents. Emodin was obtained from the CHCl_3 extract as an inhibitor of the collagenase. The concentration of emodin in the assay mixture required to give 50 % inhibition (IC_<50>) was 4.0×10^<-5>m, which was smaller than that of tetracycline or N-acetyl-L-cysteine. Of the reported anthraquinones from Rhei Rhizoma, aloeemodin and rhein showed the inhibitory effect, while sennoside A, B and aloin did not show the inhibitory effect. Acetylated products of emodin and aloe-emodin had no inhibitory activity.

• 日本生薬学会の論文
• 1988-09-20

著者

• Metori Koichi

  Department Of Biochemistry College Of Pharmacy Nihon University

• Tanaka Toshiaki

  Department Of Applied Chemistry Tokyo Institute Of Technology

• MINEO SATOSHI

  Department of Pharmacology, The Kohno Clinical Medicine Research Institute

• NIYINO YASUNORI

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Metori Koichi

  Department Of Pharmacology The Kohno Clinical Medicine Research Institute

• Satoh Toshio

  Faculty Of Pharmaceutical Science Tokushima Bunri University

• Matsumoto Hitoshi

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• SATOH TOSHIO

  Faculty of Pharmaceutical Sciences, Tokushima University of Arts and Science

• MATSUMOTO HITOSHI

  Faculty of Pharmaceutical Sciences, Tokushima University of Arts and Science

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