The Prevalence of Islet-Cell Antibodies and Complement-Fixing Islet-Cell Antibodies in Japanese Diabetics

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概要

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• The presence of complement-fixing islet-cell antibodies (CF-ICA) and islet-cell antibodies (ICA) was examined in 355 patients with different types of diabetes mellitus in the Japanese population by an indirect immunofluorescence test (IFT).<BR>The overall prevalence of ICA, which were stained as a homogenous cytoplasmic fluorescence in islet cells, was 7 per cent (5/67) in insulin-dependent (Type I) diabetics, 4 per cent (6/137) in noninsulin-dependent (Type II) diabetics treated with insulin and 2 per cent (1/58) in Type II diabetics treated with oral hypoglycemic agents. None of 84 Type II diabetics receiving diet alone and 9 diabetics associated with chronic pancreatitis had ICA. CF-ICA, which were stained as a “ring-shaped” fluorescence in a part of the cytoplasma, were demonstrated in 5 out of 12 cases (42%) whose sera possessed ICA.<BR>The lower prevalence and remarkably shorter persistence of ICA and CF-ICA in Japanese diabetics than those observed in Caucasian diabetics may be explained by the heterogenous immunological response in different races or possible heterogeneityof Type I diabetics.

• 社団法人 日本内分泌学会の論文

著者

• Tanaka Toshiaki

  Department Of Applied Chemistry Tokyo Institute Of Technology

• Sawano Shinji

  Toranomon Hospital

• KOBAYASHI TETSURO

  Toranomon Hospital

• ITOH TOKUJI

  Toranomon Hospital, Department of Endocrinology and Metabolism

• SUGIMOTO TADAO

  Toranomon Hospital, Department of Endocrinology and Metabolism

• SUWA SEIZO

  Kanagawa Childrens Medical Center, Department of Pediatrics

• TANAKA TOSHIAKI

  Department of Pediatrics, Okinaka Memorial Institute for Medical Research and Asahi Life Institute for Adult Diseases

• KOBAYASHI TETSURO

  Toranomon Hospital, Department of Endocrinology and Metabolism

• SUWA SEIZO

  Kanagawa Children's Medical Center, Department of Pediatrics

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