The Bioassay for Human Prolactin and Human Chorionic Somatomammotropin in Serum from Pregnant Women and in Amniotic Fluid
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概要
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The bioactivity of human prolactin (hPRL) and human chorionic somatomammotropin (hCS) in the sera from the pregnant women (30-40weeks of gestation) and in the amniotic fluid (37-41 weeks of gestation) were determined individually by the bioassay for lactogenic hormones using rat lymphoma cell bioassay in combination with the antibody blocking method.<BR>The bioactivity of hPRL in the pregnant sera ranged from 67 to 289ng/ml and in the amniotic fluid from 141 to 1603ng/ml. The ratio of the bioassay and RIA estimates of hPRL in the pregnant sera was 0.93±0.23 (mean±SD) and that of estimates of hPRL in the amniotic fluid was 1.04±0.26. These ratios are not significantly different from unity, which demonstrates that the bioactivity of hPRL is not significantly different from the immunoactivity.<BR>The bioactivity of hCS in the pregnant sera ranged from 5.6 to 21.8μg/ml and in the amniotic fluid from 87 to 1274ng/ml. The ratio of the bioactivity and RIA estimates of hCS in the pregnant sera was 1.48±0.20 and that of estimates of hCS in the amniotic fluid was 1.32±0.21. These ratios are significantly higher than unity, which demonstrates that the bioactivity of hCS was significantly higher than the immunoactivity. This may be due to the impurity or relatively decreased bioactivity of the hCS standard.<BR>This bioassay seems useful and convenient to measure the individual concentration of hPRL and hCS in the pregnant serum and in the amniotic fluid.
- 社団法人 日本内分泌学会の論文
著者
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Tanaka Toshiaki
Department Of Applied Chemistry Tokyo Institute Of Technology
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SHISHIBA YOSHIMASA
Division of Endocrinology and Endocrine Research Laboratory Toranomon Hospital and Okinaka Memorial
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FUKUSHIMA YASUYOSHI
Department of Gynecology and Obstetrics Toranomon Hospital and Okinaka Memorial Institute for Medica
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HORIGUCHI MASAKO
Department of Gynecology and Obstetrics Toranomon Hospital and Okinaka Memorial Institute for Medica
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TANAKA TOSHIAKI
Department of Pediatrics Toranomon Hospital and Okinaka Memorial Institute for Medical Research
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HORIGUCHI MASAKO
Department of Gynecology and Obstetrics Toranomon Hospital and Okinaka Memorial Institute for Medical Research
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