The Suppression of TSH in the Presense of the Normal PRL Responses to TRH out of 26 Patients with Primary Hyperparathyroidism
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概要
- 論文の詳細を見る
The responses of TSH and PRL to intravenous doses of 500μg of TRH were investigated in 26 patients with primary hyperparathyroidism. Fourteen patients (54%) showed low responses of TSH with peak values of less than 5μU/ml (Group A). Twelve patients showed normal responses of TSH to TRH (Group B). Among the 26, 12 cases belonging to Group A and eight in Group B were reexamined after the correction of serum calcium level by parathyroidectomy. After successful treatment, the responses of TSH to TRH in six of the 12 patients in Group A returned to normal, whereas those in the remaining six were unchanged. The responses in the eight patients in Group B after surgery were not changed when compared to those before treatment. The basal values of PRL and the responses of PRL to TRH were normal in all patients and did not change after treatment.<BR>We showed that patients with primary hyperparathyroidism have a high incidence (54%) of suppressed TSH response to TRH. Hypercalcemia was obviously one of the causative factors in inducing this abnormality in six patients. However, persistently suppressed responses of TSH to TRH were observed in the other six patients in Group A even after the correction of the serum calcium level by surgery. This finding suggests a primary failure of the TSH-regulatory mechanism in some cases of primary hyperparathyroidism.
- 社団法人 日本内分泌学会の論文
著者
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Ozawa Yasunori
Division Of Cardiology Department Of Internal Medicine St. Marianna University School Of Medicine
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Sugimoto Toshitsugu
Department Of Endocrinology/metabolism And Hematology/oncology Shimane University Faculty Of Medicin
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Sugio Toshiko
Internal Medicine 1 Shimane University Faculty Of Medicine
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SHISHIBA YOSHIMASA
Division of Endocrinology and Endocrine Research Laboratory Toranomon Hospital and Okinaka Memorial
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SHIMIZU TAEKO
Division of Endocrinology and Endocrine Research Laboratory, Toranomon Hospital and Okinaka Memorial
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NAKAZAWA HIDEKI
Division of Endocrinology, Toranomon Hospital and Okinaka Memorial Institute for Medical Research
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SHIMIZU TAEKO
Division of Endocrinology, Toranomon Hospital and Okinaka Memorial Institute for Medical Research
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SHIMIZU TAEKO
Division of Endocrinology and Endocrine Research Laboratory, Toranomon Hospital
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SHISHIBA YOSHIMASA
Division of Endocrinology, Toranomon Hospital and Okinaka Memorial Institute for Medical Research
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