Effect of Triiodothyronine or Iodide on the Thyroidal Secretion <I>In Vitro</I>: Inhibition of TSH-and Dibutyryl-Cyclic-AMP Induced Endocytosis
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概要
- 論文の詳細を見る
T<SUB>3</SUB> or iodide, at the concentration of 10<SUP>-3</SUP>M, inhibits TSH-or dibutyryl-cyclic AMP-induced thyroidal intracellular colloid droplet formation, while leaving the TSH-induced increase in cyclic AMP levels intact. The effect of T<SUB>3</SUB> appeared not to be mediated through the iodide derived from deiodination of T<SUB>3</SUB>. Those results clearly demonstrate that T<SUB>3</SUB> or iodide acts at the point beyond cyclic AMP generation and prior to the formation of intracellular colloid droplets. This is also the site at which microtubule active reagents exert their influence. Whether T<SUB>3</SUB> or iodide fits this category or acts in as yet undetermined manner remains to be established.
- 社団法人 日本内分泌学会の論文
著者
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SHISHIBA YOSHIMASA
Division of Endocrinology and Endocrine Research Laboratory Toranomon Hospital and Okinaka Memorial
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SHIMIZU TAEKO
Division of Endocrinology and Endocrine Research Laboratory, Toranomon Hospital and Okinaka Memorial
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SHIMIZU TAEKO
Division of Endocrinology and Endocrine Research Laboratory, Toranomon Hospital
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SHIMIZU TAEKO
Division of Endocrinology, Department of Medicine, Toranomon Hospital
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