Delayed Equilibrium of Pituitary Triiodothyronine (T<SUB>3</SUB>) following an Acute T<SUB>3</SUB> Administration
スポンサーリンク
概要
- 論文の詳細を見る
To reconcile the knowledge on tissue T<I>3</I> concentration with cellular metabolism or regulatory mechanism of thyroid hormone secretion, the pattern of the change of tissue T<I>3</I> concentration following an acute administration of T<I>3</I> was studied in mice. Basal T<I>3</I> concentration in serum, liver, brain and pituitary was 61, 173, 198 and 1630ng/100 g, respectively. After 0.5μg T<I>3</I> dose, T<I>3</I> concentration in serum and liver reached the maximum level 1 to 3 hrs following the administration and decreased exponentially thereafter, thus, maintaining almost constant tissue/plasma T<I>3</I> ratio. In contrast, T<I>3</I> increase in brain or pituitary was far delayed, not until 7 to 12 hrs following T<I>3</I> injection, and then decreased parallel to that in serum. Furthermore, the magnitude of increase in pituitary T<I>3</I> was limited when compared to that in liver. Thus, tissue/plasma T<I>3</I> ratio in pituitary decreased markedly after the dose of T<I>3</I>. This finding suggests the possibility that there is blood-brain barrier or blood-tissue barrier for the transport of T<I>3</I> in pituitary or brain, resulting in delayed equilibrium with that in serum. These results may also explain the delay of inhibition of TRHinduced TSH release after single dose of T<I>3</I> as recently reported by Azizi <I>et al</I>.(1975).
- 社団法人 日本内分泌学会の論文
著者
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SHISHIBA YOSHIMASA
Division of Endocrinology and Endocrine Research Laboratory Toranomon Hospital and Okinaka Memorial
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TAKAISHI MASARU
Division of Endocrinology and Endocrine Research Laboratory, Toranomon Hospital and Okinaka Memorial
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MIYACHI YOSHIE
Division of Endocrinology, Department of Medicine, Toranomon Hospital and Okinaka, Memorial Institut
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TAKAISHI MASARU
Division of Endocrinology and Endocrine Research Laboratory, Toranomon Hospital
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TAKAISHI MASARU
Division of Endocrinology, Department of Medicine, Toranomon Hospital and Okinaka, Memorial Institute for Medical Research
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MIYACHI YOSHIE
Division of Endocrinology, Department of Medicine, Toranomon Hospital and Okinaka, Memorial Institute for Medical Research
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