Role of Phospholipase D-Derived Phosphatidic Acid as a Substrate for Phospholipase A_2 in RBL-2H3 Cells

スポンサーリンク

概要

• 論文の詳細を見る

• The implications of phospholipase D (PLD) in cytosolic phospholipase A_2 (cPLA_2) activation were studied in a mast cell line, RBL-2H3,upon stimulation with antigen. Antigen-stimulated prostaglandin D_2 generation was apparently suppressed by ethanol with a concomitant decrease in phosphatidic acid (PA) formation. The prostaglandin D_2 generation was also inhibited almost completely by methyl arachidonyl fluorophosphate (MAFP), an inhibitor of cPLA_2,but not by diacylglycerol lipase inhibitor. Furthermore, stimulation with antigen resulted in an increase in lysophosphatidic acid formation, which was suppressed by MAFP in parallel with an increase in PA formation. These results suggest that PA formed by the catalytic action of PLD is used as a substrate for cPLA_2. thus PLD regulates cPLA_2 activation in antigen-stimulated RBL-2H3 cells.

• 社団法人日本薬学会の論文
• 2000-12-01

著者

• SATO Takashi

  Department of Neurosurgery, University of Yamanashi, Faculty of Medicine

• Sato T

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Sato Takashi

  京都薬科大学 病態生化学

• AKIBA Satoshi

  Department of Pathological Biochemistry, Kyoto Pharmaceutical University

• KITATANI Kazuyuki

  Department of Pathological Biochemistry, Kyoto Pharmaceutical University

• Kitatani Kazuyuki

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Akiba S

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Akiba Satoshi

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Sato Takashi

  Department Of Internal Medicine And Clinical Immunology Yokohama City University School Of Medicine

• Sato T

  Department Of Applied Chemistry Faculty Of Engineering Nagasaki University

• Sato T

  Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima

• Sato Takashi

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Sato Takashi

  Department Of Communications And Computer Engineering Kyoto University

• Sato Takashi

  Department Of Applied Biochemistry And Food Science Saga University

関連論文

• Anaplastic Ganglioglioma With Malignant Features in Both Neuronal and Glial Components : Case Report
• Anti-arthritic Action Mechanisms of Natural Chondroitin Sulfate in Human Articular Chondrocytes and Synovial Fibroblasts
• 失神を繰り返した左冠動脈起始異常による心筋梗塞の1男児例
• Diagnosis supporting algorithm for lymph node metastases from colorectal carcinoma on ^F-FDG PET/CT
• The Citrus Flavonoid, Nobiletin, Inhibits Peritoneal Dissemination of Human Gastric Carcinoma in SCID Mice
• Nobiletin (citrus flavonoid) inhibits the production of MMP-9 and peritoneal metastasis of gastric carcinoma in SCID mice
• Group IVA Phospholipase A_2-Associated Production of MMP-9 in Macrophages and Formation of Atherosclerotic Lesions(Highlighted paper selected By Editor-in-chief,Biochemistry)
• Inhibition of Cytosolic Phospholipase A_2 Suppresses Production of Cholesteryl Ester through the Reesterification of Free Cholesterol but not Formation of Foam Cells in Oxidized LDL-Stimulated Macrophages(Highlighted paper selected by Editor-in-chief,Bioc
• Antibacterial Activity of Peptides Derived from the C-Terminal Region of a Hemolytic Lectin, CEL-III, from the Marine Invertebrate Cucumaria echinata
• An anthropomorphic pelvis phantom for optimization of the diagnosis of lymph node metastases in the pelvis
• Improvement of the diagnostic accuracy of lymph node metastases of colorectal cancer in ^F-FDG-PET/CT by optimizing the iteration number for the image reconstruction
• TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis
• EFFECT OF DRUGS ON CONCANAVALIN A-INDUCED PLATELET ACTIVATION
• Triacylglycerol deposition with group IVC phospholipase A2 expression in oleate- and linoleate-stimulated Huh-7 hepatocytes
• A Case of Vertebral Artery Dissection Associated with Morning Blood Pressure Surge
• Glucose Uptake in Rat Skeletal Muscle L6 Cells Is Increased by Low-Intensity Electrical Current Through the Activation of the Phosphatidylinositol-3-OH Kinase (PI-3K) / Akt Pathway
• MEK1/2 and PKC β II/ε Are Target Molecules for Nobiletin-Induced Suppression of ProMMP Production and Augmentation of TIMP-1 Production in HT-1080 Cells
• Synthesis, Structure, and Properties of Polyacetylenes Possessing Chiral Spirobifluorene Moieties in the Side Chain
• Synthesis of acetylene-functionalized [2]rotaxane monomers directed toward side chain-type polyrotaxanes
• Triacylglycerol Deposition with Group IVC Phospholipase A2 Expression in Oleate- and Linoleate-Stimulated Huh-7 Hepatocytes
• PHYSIO-HISTOLOGICAL STUDIES ON THE PHYSIOLOGICAL OBESITY OF MEAT PIGS, (REPORT IX), ESPECIALLY ON THE OCCURRENCE OF GLYCOGEN WITHIN THE NUCLEI AND CYTOPLASMS OF THE ZONA RETICULARIS IN THE ADRENALS OF WILD BOARS AND LANDRACE MEAT PIGS IN COMPARISON WITH T
• Discoordinate Regulation of Expression of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases-3 in Bovine Endometrial Stromal Cells on Type-I Collagen Gel
• Progression of Pericellular Proteolysis by EMMPRIN-bound Active Matrix Metalloproteinase 1 on the Surface of Tumor Cells
• An Antiprogesterone, Onapristone, Enhances the Gene Expression of Promatrix Metatloproteinase 3/Prostromelysin-1 in the Uterine Cervix of Pregnant Rabbit
• Inhibition of AP-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of TIMP-1 production and suppression of production of MMPs-1 and -9 in human fibrosarcoma HT-1080 cell
• Involvement of EMMPRIN/CD147 in pericellular proteolysis by augmenting the production of MMP-1 and localization of MMP-1 on tumor cell surface
• Role of Phospholipase D-Derived Phosphatidic Acid as a Substrate for Phospholipase A_2 in RBL-2H3 Cells
• Involvement of Lipoxygenase Pathway in Docosapentaenoic Acid-Induced Inhibition of Platelet Aggregation
• Ceramide Enhances Susceptibility of Membrane Phospholipids to Phospholipase A_2 through Modification of Lipid Organization in Platelet Membranes
• Stimulation by Ceramide of Phospholipase A_2 Activation through a Mechanism Related to the Phospholipase C-Initiated Signaling Pathway in Rabbit Platelets
• High Glucose-Induced Cytosolic Phospholipase A_2 Activation Responsible for Eicosanoid Production in Rat Mesangial Cells
• Sphingosine Enhances Arachidonic Acid Liberation in Response to U46619 through an Increase in Phospholipase A_2 Activity in Rabbit Platelets
• Lipid Peroxide Overcomes the Inability of Platelet Secretory Phospholipase A_2 to Hydrolyze Membrane Phospholipids in Rabbit Platelets
• Stimulation of Platelet-Activating Factor Synthesis in Polymorphonuclear Leukocytes from Streptozotocin-Induced Diabetic Rats
• INHIBITORY MECHANISM OF LONG-CHAIN, UNSATURATED FATTY ACIDS ON PLATELET ACTIVATION
• Augmentation of Gene Expression and Production of Promatrix Metalloproteinase 2 by Propionibacterium acnes-Derived Factors in Hamster Sebocytes and Dermal Fibroblasts: A Possible Mechanism for Acne Scarring
• Synthesis and Characterization of Poly[3]rotaxane through the Mizoroki-Heck Coupling Polymerization of Divinyl-functionalized [3]Rotaxane
• Outcome of pediatric patients with Langerhans cell histiocytosis treated with 2 chlorodeoxyadenosine : a nationwide survey in Japan
• Crystallization and preliminary X-ray analysis of salicylate hydroxylase from Pseudomonas putida S-1
• Timing Analysis Considering Temporal Supply Voltage Fluctuation
• Successive Pad Assignment for Minimizing Supply Voltage Drop(Power/Ground Network, VLSI Design and CAD Algorithms)
• Simultaneous bilateral laparoscopic adrenalectomy in ACTH-independent macronodular adrenal hyperplasia
• Contingent negative variation in children with anorexia nervosa
• EFFECT OF INTRACELLULAR AND EXTRACELLULAR pH ON SHAPE CHANGE OF HUMAN ERYTHROCYTES INDUCED BY AMPHIPHILIC DRUGS
• Antibacterial Peptides Derived from the C-Terminal Domain of the Hemolytic Lectin, CEL-III
• Pulmonary Hyalinizing Granuloma with Laryngeal and Subcutaneous Involvement : Report of a Case Successfully Treated with Glucocorticoids
• Effects of Organo-mineral Complexes on Flocculation, Settlement and Vertical Distribution of Bioelements in Soil Suspensions (Environment)
• Granuloma Maturation in the Rat is Advanced by the Oral Administration of Eucommia ulmoides OLIVER Leaf
• The Promoting Effect of Eucommiol from Eucommiae Cortex on Collagen Synthesis
• Changes in Lactate Dehydrogenase and 3-Hydroxyacetyl-CoA Dehyderogenase Activities in Rat Skeletal Muscle by the Administration of Eucommia ulmoides OLIVER Leaf with Spontaneous Running-training
• Improvement in the Turnover Rate of the Stratum Corneum in False Aged Model Rats by the Administration of Geniposidic Acid in Eucommia ulmoides OLIVER Leaf
• Successful Treatment of Necrotizing Fasciitis and Toxic Shock Syndrome by Hip Amputation and Endotoxin Hemoadsorption
• Differential Effect of UV-B and UV-C on DNA Damage in L-132 Cells
• Mode of Gene Damage Induced by Exposure to UVB and Some Radical Species (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
• Interaction between Dimethylarsenics and Active Oxygen Species in the Induction of Gene Damage (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
• Application of Piezoelectric Film of Vinylidene Fluoride-Trifluoroethylene Copolymer to a Highly Sensitive Miniature Hydrophone : Ultrasonic Transduction
• Short Pulse Response of UltrasonicTransducer Mode of Piezoelectric Copolymer Films of Vinylidene Fluoride-Trifluoroethylene : Ultrasonic Transduction
• Wide-band Multi-layer Ultrasonic Transducers Made of Piezoelectric Films of Vinylidene Fluoride-Trifluoroethylene Copolymer : Ultrasonic Transduction
• Requirement of Calcium Influx for Hydrolytic Action o fMembrane Phospholipids by Cytosolic Phospholipase A Rather than Mitogen-Activated Protein Kinase Activation in FcεRI-stimulated Rat Peritoneal Mast Cells
• Importance of the Phospholipase D-Initiated Sequential Pathway for Arachidonic Acid Release and Prostaglandin D_2 Genration by Rat Peritoneal Mast Cells
• Diffuse Mineralization of Extraskeletal Chondroma: A Case Report
• The Promoting Effects of Geniposidic Acid and Aucubin in Eucommia ulmoides OLIVER Leaves on Collagen Synthesis
• Frequency Stabilizatiorn of a Semiconductor Laser under Direct Frequency Shift Keying Using the Saturated Absorption Signal
• Angiomyofibroblastoma of the female urethra
• Sphingosine Enhances Phosphatidylinositol 4-Kinase Activity in Rabbit Platelets
• Multi-Stage Creep Effect in Consolidation of Tofu and Okara as Soft Colloids
• High frequency of β-lactamase-negative, ampicillin-resistant strains of Haemophilus influenzae in patients with chronic bronchitis in Japan
• High-dose chemotherapy in children with metastatic hepatoblastoma
• MECHANISMS OF CD34 EXPRESSION BY MURINE HEMATOPOIETIC STEM CELLS
• Influence of Cytoplasmic pH on the Aggregation and Ca^ Mobilization in Rabbit Platelets
• Autoimmune Neutropenia of Infancy with Multiple Brain Abscesses during the Course of Human Herpesvirus-6 Infection
• Detection of p53 Gene Mutations in Aspiratopm Biopsy Specimens from Suspected Breast Cancers by Polymerase Chain Reaction-Single Strand Conformation Polymorphism Analysis
• Translational Augmentation of Pro-matrix Metalloproteinase 3 (Prostromelysin 1) and a Tissue Inhibitor of Metalloproteinases (TIMP)-1 mRNAs by Epidermal Growth Factor and Transforming Growth Factor α, but not by Interleukin 1α or 12-O-Tetradecanoylphorbol
• VEGF-Enhanced Proliferation under Hypoxia by an Autocrine Mechanism in Human Vascular Smooth Muscle Cells
• High tibial osteotomy using two threaded pins and figure-of-eight wiring fixation for medial knee osteoarthritis : 14 to 24 years follow-up results
• Surgical Treatment for Cervical Spinal Lesions in Patients with Rheumatoid Arthritis : Advancement from 2000 Onward
• Roles of matrix metalloproteinases and their inhibitors during extracellular matrix remodeling in female reproductive tract
• Cellular Function of Calcium-Independent Phospholipase A_2(Diversity of Phospholipase A_2 Enzymes)
• Regrowth Interface Quality Dependence on Thermal Cleaning of AlGaInAs/InP Buried-Heterostructure Lasers
• Three-dimensional lower extremity alignment in the weight-bearing standing position in healthy elderly subjects
• A Cystine Motif in A Novel Endogenous Inhibitor of Phenoloxidase
• Utilization of Fluorescent Labeled Analogs Designed based on "Camouflaging Substitution" for SAR of Phenoloxidase Inhibitor, POI
• Synthesis of N-(Trifluoromethyl-2-pyridinyl)arenesulfonamides as an Inhibitor of Secretory Phospholipase A2
• Electric field measurement by laser Doppler velocimeter with charged liquid droplets
• Minimizing Page Fetches for Permuting Information in Two-Level Storage : Part 1. Generalization of the Floyd Model
• The usefulness of fully three-dimensional OSEM algorithm on lymph node metastases from lung cancer with ^F-FDG PET/CT
• TISSUE POLYPEPTIDE ANTIGEN AND CANCER ANTIGEN 125 IN PREGNANCY : THESE TWO CANCER-RELATED ANTIGENS ARE ONCOPLACENTAL?
• Suppression of Oxidized LDL-Induced PDGF Receptor β Activation by Ginkgo Biloba Extract Reduces MMP-1 Production in Coronary Smooth Muscle Cells
• Triptolide, a novel diterpenoid triepoxide, from tripterygium wilfordii hook. f. suppresses the production and gene expression of matrix metalloproteinases-1 and -3 and augments the expression of tissue inhibitors of metalloproteinases-1 and -2 in human s
• Synthesis of N-[2-(2,4-Difluorophenoxy)trifluoromethyl-3-pyridyl]sulfonamides and Their Inhibitory Activities against Secretory Phospholipase A2
• C-12-45 A sensor-based self-adjustment approach for controlling I/O buffer impedance
• Hyperthermia Enhances Novel Anti-Metastatic and Anti-Proliferative Activities of Cisplatin on Human Tumor Cells
• Electrostatic scavenging of submicron particles aided by the hydrodynamic effect of particle vibration
• Room-Temperature Continuous-Wave Operation of 1.3-μm Transistor Laser with AlGaInAs/InP Quantum Wells
• 超低出生体重児のブドウ球菌性熱傷様皮膚症候群 : 原因メチシリン耐性黄色ブドウ球菌の分子性状解析とマルチプレックスPCRとリアルタイムPCRによる迅速診断
• Glucose Uptake in Rat Skeletal Muscle L6 Cells Is Increased by Low-Intensity Electrical Current Through the Activation of the Phosphatidylinositol-3-OH Kinase (PI-3K)/Akt Pathway
• Structural Evolution of Sputtered Molybdenum Thin Film Growth
• Power Distribution Network Optimization for Timing Improvement with Statistical Noise Model and Timing Analysis
• Effect of a peroxynitrite scavenger, a manganese-porphyrin compound on airway remodeling in a murine asthma
• Negative role of Sphingomyelin Synthase 2 in EL4 cells infiltration due to the deterioration of ICAM1/LFA1 system

もっと見る 閉じる

スポンサーリンク