Effect of Propranolol on Hyphae Formation Signal in Candida albicans(Microbiology)
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概要
- 論文の詳細を見る
Candida albicans (C. albicans) is known as an opportunistic pathogen that changes from a yeast form to a hyphae form in response to various outside environmental signals. The addition of propranolol inhibited hyphae formation of C. albicans. Propranolol inhibited the expression of agglutinin like sequence 3 (ALS3) and ALS8mRNA, which are regulated by the cAMP-EFG1 pathway in C. albicans. Propranolol did not affect the expression of CST20, HST7 or CPH1mRNA, which are components of the mitogen-activated protein (MAP) kinase cascade in C. albicans. The expression of CYR1mRNA, which encodes adenylate cyclase of C. albicans, was not affected by propranolol. These findings indicated that the interruption of hyphae formation by propranolol is caused by inhibition of the cAMP-EFG1 pathway, but not effects on the MAP kinase cascade.
- 2009-01-01
著者
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Mikami Takeshi
Department Of Veterinary Microbiology Faculty Of Agriculture The University Of Tokyo
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Mikami T
Department Of Microbiology Tohoku Pharmceutical University
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Mikami Takeshi
東北薬科大学 微生物学
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渡部 俊彦
東北薬大
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Ogasawara Ayako
Department Of Microbiology Tohoku Pharmceutical University
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WATANABE TOSHIHIKO
Department of Surgery, Tachikawa Kyosai Hospital
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Watanabe T
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A
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Watanabe T
Dept. Clin. Biochem. Sch. Pharm. Sci. Tokyo College Of Pharmacy
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Watanabe T
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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Mikami Takeshi
Department Of Epizootiology Faculty Of Veterinary Medicine Hokkaido University
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MATSUMOTO Tatsuji
Department of Microbiology, Tohoku Pharmacentical University
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UENO Yukihiro
Department of Microbiology, Tohoku Pharmceutical University
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MARUYAMA Naoko
Department of Microbiology, Tohoku Pharmceutical University
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KANNO Mika
Department of Microbiology, Tohoku Pharmceutical University
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MURAKAMI Tomonori
Department of Microbiology Tohoku College of Pharmacy
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Matsumoto T
Department Of Microbiology Tohoku Pharmceutical University
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Kanno Mika
Department Of Microbiology Tohoku Pharmceutical University
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Kanno Mika
Department Of Biology Faculty Of Science Niigata University
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Ueno Yukihiro
Department Of Microbiology Tohoku Pharmceutical University
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Ueno Yukihiro
Department Of Critical Care And Emergency Medicine Tsukuba Medical Center
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Maruyama Naoko
Department Of Microbiology Tohoku Pharmceutical University
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Watanabe Takafumi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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Watanabe T
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Ogasawara Ayako
Department Of Microbiology Tohoku Pharmaceutical University
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松本 達二
東北薬大
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Watanabe Takafumi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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Watanabe Toshihiko
Department Of Aeronautics And Astronautics University Of Tokyo
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Ogasawara Ayako
Department of Microbiology, Tohoku Pharmaceutical University
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松本 達二
Department of Microbiology, Tohoku Pharmaceutical University
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MIKAMI Takeshi
Department of Cardiovasology, Surugadai Nihon University Hospital
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