Production of Interleukin-1 Activity of Kupffer Cells from Mice Treated with the Acidic Mannan Fraction of Bakers' Yeast

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概要

• 論文の詳細を見る

• We investigated the production of interleukin-1 (IL-1) activity by Kupffer cells (KC) from mice treated with a neutral mannan fraction (WNM) or an acidic mannan fraction (WAM025) from baker's yeast (Saccharomyces cerevisiae) in vivo and in vitro. The mice administered WAM025 showed an increase in the number of KC and the IL-1 production compared with mice administered WNM. In an in vitro stimulation assay using KC from a normal mouse, it was also found that WAM025 displayed an increase in IL-1 production. Diisopropyl fluorophosphate completely inhibited the production of IL-1 by KC from the mice administered WAM025.

• 公益社団法人日本薬学会の論文
• 2002-11-01

著者

• Okawa Yoshio

  Department of Infection and Host Defense, Tohoku Pharmaceutical University

• WATANABE TOSHIHIKO

  Department of Surgery, Tachikawa Kyosai Hospital

• Suzuki Masuko

  Department Of Microbiology Tohoku College Of Pharmacy

• SUZUKI MASUKO

  Tohoku College of Pharmacy

• Suzuki Masuko

  Department Of Microbiology Tohoku Pharmaceutical University

• ABE Kouji

  Department of Microbiology Tohoku Pharmaceutical University

• SASAKI Hiroyoshi

  Department of Microbiology Tohoku Pharmaceutical University

• Suzuki M

  Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University

• Suzuki M

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Okawa Yoshio

  Department Of Hygienic Chemistry Tohoku Pharmaceutical University:department Of Microbiology Tohoku

• Abe K

  Drug Metabolism And Pharmacokinetics Research Laboratories Sankyo Co. Ltd.

• Watanabe T

  Fukuyama Univ. Hiroshima Jpn

• Abe Kouji

  Department Of Functional Polymer Science Shinshu University

• Watanabe Toshihiko

  Department Of Aeronautics And Astronautics University Of Tokyo

• SUZUKI Masuko

  Department of Hygienic Chemistry, Tohoku College of Pharmacy

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