PROTECTIVE EFFECT OF ACIDIC MANNAN FRACTION OF BAKERS' YEAST AGAINST STAPHYLOCOCCUS AUREUS INFECTION IN MICE
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概要
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Protective activity of an acidic fraction of bakers' yeast mannan containing protein and phosphorus, designated as WAM025,against infection of Staphylococcus aureus βH 248 strain in mice was investigated. WAM025 elicited a marked increase in the survival ration of mice challenged with viable cells of the S.aureus strain, 5×10^8 cells per mouse, when the fraction was administered to mice 150 mg/kg/d, 5 times, intraperitoneallyl. The effect was stronger than that of WNM, a neutral fraction of mannan obtained from the same bakers' yeast. The difference seemed to correlate with the strength of activating effects of WAM025 and WNM on the reticuloendotherial system of the host animal. WAM025 induced higher activities of serum lysozyme and carbon clearance in mice than WNM. Also, mice treated with WAM025 showed a greater increase in number and activity of oxygengenerating blood polymorphonuclear leucocytes than mice treated with WNM.
- 公益社団法人日本薬学会の論文
著者
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SUZUKI SHIGEO
The Second Department of Internal Medicine Saitama Medical School
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Okawa Yoshio
Department of Infection and Host Defense, Tohoku Pharmaceutical University
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Suzuki Masuko
Department Of Microbiology Tohoku College Of Pharmacy
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HASHIMOTO KAZUHIKO
Department of Surgery, Sakai Municipal Hospital
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SUZUKI MASUKO
Tohoku College of Pharmacy
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Suzuki Shigeo
Department Of Microbiology Tohoku Pharmaceutical University
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OKURA YASUSHI
Department of Microbiology
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SUZUKI KO
Department of Microbiology
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Suzuki Masuko
Department Of Microbiology Tohoku Pharmaceutical University
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Suzuki M
Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University
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Suzuki M
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Okawa Y
Department Of Infection And Host Defense Tohoku Pharmaceutical University
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Okawa Y
Second Department Of Hygienic Chemistry Tohoku College Of Pharmacy
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Okawa Yoshio
Department Of Hygienic Chemistry Tohoku Pharmaceutical University:department Of Microbiology Tohoku
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Suzuki Ko
Department Of Microbiology Tohoku College Of Pharmacy
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Hashimoto Kazuhiko
Department Of Microbiology:tohoku College Of Pharmacy
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Suzuki Shigeo
The Second Department Of Hygienic Chemistry Tohoku College Of Pharmacy
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Hashimoto Kazuhiko
Department Of Chemistry And Materials Technology Kyoto Institute Of Technology
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Hashimoto Kazuhiko
Department Of Applied Chemistry Faculty Of Engineering Kogakuin University
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SUZUKI Masuko
Department of Hygienic Chemistry, Tohoku College of Pharmacy
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