GROWTH-INHIBITION OF LEUKEMIA L-1210 ASCITES TUMOR BY COMBINATION OF CARRAGEENAN AND MITOMYCIN C IN VIVO
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概要
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A purified ι-carrageenan prepared by means of pronase digestion and fractional precipitation with KCl was in vestigated for its growth-inhibitory effect on mouse leukemia L-1210 transplanted in (C57BL/6 × DBA/2)F_1 (BDF_1) mice. This carrageenan specimen was not growth-inhibitory on this tumor when it was administered alone in a dose of 0.1 to 10 mg/kg/d, 4 times. However, in combination with a small amount of mitomycin C, 0.25 mg/kg/d, a remarkable tumor growth-inhibition has manifested affording a complete regression of this tumor. Acid phosphatase α-galactosidase and active oxygen generation activities of the peritoneal exudate cells in the carrageenan-administered mice were remarkably higher than those of the control mice. Therefore, the booster effect of this carrageenan preparation on antitumor activity mitomycin C is assumed to be associated with the inflammatory activity of this sulfated polysaccharide.
- 公益社団法人日本薬学会の論文
著者
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Mikami T
Department Of Microbiology Tohoku Pharmceutical University
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Mikami Takeshi
東北薬科大学 微生物学
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SUZUKI Shigeo
Tohoku College of Pharmacy
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MATSUMOTO TATSUJI
Tohoku College of Pharmacy
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MIKAMI TAKESHI
Tohoku College of Pharmacy
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OKAWA YOSHIO
Tohoku College of Pharmacy
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SUZUKI MASUKO
Tohoku College of Pharmacy
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TAGUCHI AKIRA
Tohoku College of Pharmacy
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SUZUKI KO
Tohoku College of Pharmacy
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Suzuki Shigeo
Department Of Microbiology Tohoku Pharmaceutical University
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Matsumoto T
Department Of Microbiology Tohoku Pharmceutical University
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Suzuki Masuko
Department Of Microbiology Tohoku Pharmaceutical University
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Suzuki M
Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University
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Suzuki M
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Okawa Y
Department Of Infection And Host Defense Tohoku Pharmaceutical University
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Okawa Y
Second Department Of Hygienic Chemistry Tohoku College Of Pharmacy
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Suzuki Ko
Department Of Microbiology Tohoku College Of Pharmacy
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松本 達二
東北薬大
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