Production of Leukotrienes from Mouse Peritoneal Macrophages by Treatment with a Neutral Subfraction of Bakers' Yeast Mannan

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概要

• 論文の詳細を見る

• We concluded that a neutral subfraction of mannan from bakers' yeast (Saccharomyces cerevisiae wild type strain), abbreviated as WNM, was able to induce the release of leukotrienes from mouse peritoneal macrophages (Mφ). The culture supernatant fluid of Mφ from normal mice cultured with WNM caused a marked contraction of guinea pig ileum. This activity was inhibited by pretreatment of Mφ with inhibitor of phospholipase A_2 or lipoxygenase before Mφ were treated with WNM, and by treatment of the incubation bath with a slow reacting substance antagonist, FPL55712. On the other hand, pretreatment of Mφ with a cyclooxygenase inhibitor potentiated contractile response of ileum by culture supernatant fluid of Mφ. A high performance liquid chromatographic analysis of a culture supernatant fluid of Mφ treated with WNM demonstrated the presence of leukotrienes C_4 and D_4,and their related compounds.

• 公益社団法人日本薬学会の論文

著者

• Nagase Toshihiko

  Department Of Microbiology And Second Department Of Hygienic Chemistry Tohoku College Of Pharmacy

• Mikami Takeshi

  Department Of Veterinary Microbiology Faculty Of Agriculture The University Of Tokyo

• Mikami T

  Department Of Microbiology Tohoku Pharmceutical University

• Mikami Takeshi

  東北薬科大学 微生物学

• SUZUKI Shigeo

  Department of Physics, Faculty of Science, Tokyo University of Science

• Suzuki Masuko

  Department Of Microbiology Tohoku College Of Pharmacy

• Mikami Takeshi

  Department Of Epizootiology Faculty Of Veterinary Medicine Hokkaido University

• ISHITANI Kouki

  Department of Microbiology and Second Department of Hygienic Chemistry, Tohoku College of Pharmacy

• HARAKAWA Miki

  Department of Microbiology and Second Department of Hygienic Chemistry, Tohoku College of Pharmacy

• SUZUKI MASUKO

  Tohoku College of Pharmacy

• Suzuki Shigeo

  Department Of Microbiology Tohoku Pharmaceutical University

• Matsumoto T

  Department Of Microbiology Tohoku Pharmceutical University

• Suzuki Masuko

  Department Of Microbiology Tohoku Pharmaceutical University

• Suzuki M

  Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University

• Suzuki M

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Nagase Toshihiko

  Department Of Applied Chemistry Faculty Of Science And Technology Keio University

• Ishitani Kouki

  Department Of Microbiology:second Department Of Hygienic Chemistry:tohoku College Of Pharmacy

• 松本 達二

  東北薬大

• Suzuki Shigeo

  Department Of Applied Biological Chemistry The University Of Tokyo

• Harakawa Miki

  Department Of Microbiology And Second Department Of Hygienic Chemistry Tohoku College Of Pharmacy

• MIKAMI Takeshi

  Department of Cardiovasology, Surugadai Nihon University Hospital

• SUZUKI Masuko

  Department of Hygienic Chemistry, Tohoku College of Pharmacy

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