Antifungal Mechanism of Hinokitiol against Candida albicans(Microbiology)

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概要

• 論文の詳細を見る

• The growth of Candida albicans was dose-dependently inhibited by addition of hinokitiol. The sensitivity of C. albicans to hinokitiol under aerobic conditions was higher than that under anaerobic conditions. Amount of ATP in C. albicans was not inhibited by hinokitiol under both conditions. The expression of mRNAs related to the growth signal, CYR1 and RAS1, was inhibited by hinokitiol. These findings suggested that the growth inhibition of C. albicans by hinokitiol was due to the interruption of RAS-signal transmission, such as the cAMP pathway.

• 公益社団法人日本薬学会の論文
• 2008-04-01

著者

• Mikami Takeshi

  Department Of Veterinary Microbiology Faculty Of Agriculture The University Of Tokyo

• Mikami T

  Department Of Microbiology Tohoku Pharmceutical University

• Mikami Takeshi

  東北薬科大学 微生物学

• 渡部 俊彦

  東北薬大

• Ogasawara Ayako

  Department Of Microbiology Tohoku Pharmceutical University

• WATANABE TOSHIHIKO

  Department of Surgery, Tachikawa Kyosai Hospital

• Watanabe T

  Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A

• Watanabe T

  Dept. Clin. Biochem. Sch. Pharm. Sci. Tokyo College Of Pharmacy

• Watanabe T

  Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu

• Mikami Takeshi

  Department Of Epizootiology Faculty Of Veterinary Medicine Hokkaido University

• MATSUMOTO Tatsuji

  Department of Microbiology, Tohoku Pharmacentical University

• KOMAKI Nami

  Department of Microbiology, Tohoku Pharmaceutical University

• SATO Norifumi

  R&D Laboratories, EN Otsuka Phamaceutical Co., Ltd.

• MURAKAMI Tomonori

  Department of Microbiology Tohoku College of Pharmacy

• Matsumoto T

  Department Of Microbiology Tohoku Pharmceutical University

• Konno Nao

  Department Of Microbiology Tohoku Pharmaceutical University

• Komaki Nami

  Department Of Microbiology Tohoku Pharmaceutical University

• Sato N

  R&d Laboratories En Otsuka Phamaceutical Co. Ltd.

• Watanabe Takafumi

  Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu

• Watanabe T

  School Of Pharmacy Tokyo University Of Pharmacy And Life Science

• Ogasawara Ayako

  Department Of Microbiology Tohoku Pharmaceutical University

• 松本 達二

  東北薬大

• Watanabe Takafumi

  Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu

• Watanabe Toshihiko

  Department Of Aeronautics And Astronautics University Of Tokyo

• Ogasawara Ayako

  Department of Microbiology, Tohoku Pharmaceutical University

• 松本 達二

  Department of Microbiology, Tohoku Pharmaceutical University

• MIKAMI Takeshi

  Department of Cardiovasology, Surugadai Nihon University Hospital

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