Interferon-Inducing Activity of Acidic Polysaccharides:II. Induction of Rabbit Serum Interferon by Chemically Phosphorylated Polysaccharides1

概要

論文の詳細を見る
Readily available polysaccharides, amylopectin, amylose, dextrin, and yeast mannan. were chemically phosphorylated using polyphosphoric acid in the presence of a tertiary amine, and the resultant phosphates were examined for their interferon-inducing activity in rabbits employing an assay system consisting of a primary culture of rabbit kidney cells and vesicular stomatitis virus. All the phosphates were shown to be active as interferon inducer, and, especially, the activity of those containing more than 2% phosphorus were quite strong. Interfnons evoked by the above phosphates resembled those induced by bacterial endotoxin, e. g., the viral inhibiting activity was susceptible to heat treatment, low pH and tryptic digestion. Since all the parent polysaccharides showed no interferon-inducing activity. it is reasonable to assume that the activc center of these inducers might reside or be due to the anionic phosphate groups.
財団法人学会誌刊行センターの論文