マウス緑膿菌感染に対する酵母マンナンの防御効果

概要

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In order to clarify the protective effects and the mechanisms of both mannans, a neutral mannan (WNM) and an acidic mannan (WAM025) fractions from bakers' yeast, Saccharomyces cerevisiae, against Pseudomonas aeruginosa infection in mice, we measured anti-P. aerugonosa, antibody titers in the mice and in vitro bacterial-growth inhibitory activity of the phagocytes isolated from the mice. The sera derived from mannans-untreated P. aeruginosa-infected mice showed significant levels of anti-P. aerugonosa antibody. On the other hand, the sera from the mannans-treated P. aeruginosa-infected mice little showed the antibody titers, indicating the infection- protecting activities of the mannans. The P. aeruginosa growth inhibitory activity of peritoneal phagocytes, macrophages and polymorphonuclear leucocytes, in mice administered with the mannans was significantly enhanced compared with the activity of those from the untreated mice.
東北薬科大学の論文