担がんマウスのCandida albicans感染防御におけるリゾチームの役割

概要

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In order to further demonstrate the protective mechanism of sarcoma 180 tumor-bearing mice against Candida albicans infection, we investigated the role of lysozyme. The lysozyme activity of serum and fixed number of polymorphonuclear leucocytes (PMN) from mice 1 week after sarcoma 180 tumor implantation exhibited a slight increase compared with that of PMN from the control mice. On the other hand, the activity of serum and PMN from mice 3 weeks after the tumor implantation increased about 2- and 4-fold higher than that of the cells from normal mice. When the yeast- and mycelial-form cells of C. albicans were treated with 50μg/ml of commercial lysozyme, the mycelial-form cells showed higher susceptibility in the candidacidal activity of the lysozyme than the yeast-form cells. From these results, it has been demonstrated that lysozyme plays an important role in the protection of tumor-bearing mice against Candida albicans infection together with the other protective factors.
東北薬科大学の論文